Sleep Guide · Spoke 15

ADHD and Sleep in Adults: Understanding the Delayed Body Clock

Many adults with ADHD lie awake in the evening, not because they do not know better, but because their body clock runs late. Why this is so, what melatonin and light may do, how the timing of stimulants plays into it, and why poor sleep amplifies ADHD symptoms.

Shukri Jarmoukli · Physician, Integrative Medicine · ViveCura Berlin
My Starting Point

When an adult with ADHD tells me "I just cannot fall asleep," I rarely hear a lack of willpower and very often see a shifted biology. In a large proportion of people with ADHD the body clock runs late. The evening rise in melatonin, the body's own signal to power down, comes later than in other people. Bijlenga 2013 in Journal of Sleep Research and van Andel 2021 in Chronobiology International made this measurable. This is not an excuse but a diagnostic trail. And it changes treatment fundamentally: a delayed clock responds to light and timing, not primarily to a sleeping pill. In ADHD, sleep is not a side issue but its own treatment lever. In this spoke I organize the evidence so that you understand what might be going on with you and which steps make sense.

This spoke is the ADHD building block in the sleep cluster. We clarify why the body clock is often delayed in ADHD, how this differs from classic insomnia, what melatonin may do as a chronobiotic, why the time of intake of stimulants matters, how morning light helps, and why sleep loss amplifies ADHD symptoms. Plus four KPNI lenses, three study boxes with DOI, a reframe of what does not work, a safety note and concrete levers.

Why the Body Clock Often Runs Late in ADHD

The central observation of sleep research in ADHD is surprisingly concrete. It is usually not that people sleep poorly in general, but that their sleep is shifted later in time. Technically this is called delayed sleep phase disorder or Delayed Sleep Phase Syndrome (DSPS). The internal pacemaker in the brain, the suprachiasmatic nucleus, simply runs late.

The best marker for this is the dim-light melatonin onset (DLMO), the time in the evening at which the melatonin level rises under dimmed light. This rise is the most reliable internal signal for the start of the biological night. In ADHD this signal comes late.

Study · Case-Control, Adults

Melatonin and Temperature Profile in Adults with ADHD and Delayed Sleep

Human Denise Bijlenga and colleagues studied in 2013 in Journal of Sleep Research 12 medication-naive adults with ADHD and delayed sleep phase compared with 12 healthy controls, over five consecutive days and nights in the home setting. The DLMO in the ADHD group was on average about 1.5 hours later than in controls. Notably: daily bedtimes were markedly more variable in ADHD, while the melatonin profiles themselves remained stable. The interval between DLMO and actual sleep onset was on average one hour longer in those affected. Core and skin temperature were delayed in parallel with melatonin. The authors concluded that the sleep problems in ADHD are linked to a shift and dysregulation of the circadian rhythm.

Bijlenga D, Van Someren EJW, Gruber R, et al. J Sleep Res. 2013;22(6):607-16. doi:10.1111/jsr.12075 · PMID: 23952346

How widespread this is shown by a large data summary. van Andel 2021 in Chronobiology International found among the adults with ADHD and delayed sleep phase studied that 77 percent had a DLMO after 9 pm, on average at 11:43 pm. This means: for many people an internal signal to fall asleep before midnight is barely available biologically. Whoever still lies in bed at 10 pm is fighting against their own biology.

A Delayed Clock Is Not the Same as Insomnia

This distinction is therapeutically decisive and is often overlooked. With classic insomnia a person sleeps poorly in general, regardless of the time. With a delayed sleep phase the sleep itself is often restful, just shifted in time. If you let the person sleep freely, they would for example fall asleep at 2 am and sleep through until 10 am.

Delayed Sleep Phase (DSPS)

Late sleep onset, late waking, pronounced evening type. The sleep itself is usually fine; the conflict arises with work and social schedules. Responds to light and timing.

Classic Insomnia

Difficulty falling or staying asleep independent of the desired time, often with rumination and tension. Responds more to sleep restriction and cognitive behavioral therapy for insomnia.

Restless Legs Syndrome

An urge to move and unpleasant sensations in the legs in the evening that disturb falling asleep. Occurs more often in ADHD and should be assessed in its own right.

Sleep Apnea

Breathing pauses with loud snoring and unrefreshing sleep. Produces daytime sleepiness and concentration problems that resemble ADHD symptoms. Needs a sleep-medicine evaluation.

Snitselaar 2016 in Journal of Attention Disorders describes the sleep profile of many adults with ADHD as typical of a delayed sleep phase disorder: longer objective sleep-onset latency independent of insomnia complaints, disturbed sleep maintenance, delayed wake-up time and pronounced evening orientation. Those who recognize these patterns treat differently, namely with zeitgebers instead of sedation.

What Melatonin Really Can and Cannot Do

Melatonin is often misunderstood as a gentle sleeping pill. That is only half the truth. In the use relevant to ADHD, melatonin may act as a chronobiotic: it shifts the body clock earlier when taken in a low dose and, above all, at the right time, namely a few hours before one's own DLMO. A high dose late at night tends to make you tired but does not reliably shift the clock.

Study · RCT, Children

Melatonin in ADHD and Chronic Sleep-Onset Insomnia

RCT Kristiaan van der Heijden and colleagues published in 2007 in Journal of the American Academy of Child and Adolescent Psychiatry a randomized, double-blind, placebo-controlled trial with 105 medication-free children (6 to 12 years) with ADHD and chronic sleep-onset insomnia. Over four weeks they received 3 or 6 mg melatonin or placebo. Sleep-onset time shortened under melatonin by about 27 minutes and was delayed under placebo. The DLMO shifted under melatonin about 44 minutes earlier. Total sleep time increased. Important and honest: the study showed no effect on behavior, cognitive performance or quality of life. Melatonin thus improved the sleep timing but was no cure-all for the ADHD symptoms themselves.

Van der Heijden KB, Smits MG, Van Someren EJW, et al. J Am Acad Child Adolesc Psychiatry. 2007;46(2):233-41. doi:10.1097/01.chi.0000246055.76167.0d · PMID: 17242627

Study · RCT, Adults

Chronotherapy with Melatonin in Adults with ADHD and DSPS

RCT Emma van Andel and colleagues published in 2021 in Chronobiology International a three-arm randomized clinical trial with 51 adults (18 to 55 years) with ADHD and delayed sleep phase. Over three weeks they received sleep education plus either 0.5 mg placebo, 0.5 mg melatonin, or 0.5 mg melatonin plus 30 minutes of morning light therapy (10,000 lux). Melatonin administration started three hours before the individual DLMO. Result: melatonin shifted the DLMO about 1.5 hours earlier, melatonin plus light by almost two hours. Self-reported ADHD symptoms decreased under melatonin by 14 percent. Two weeks after the end of treatment, however, DLMO and symptoms were back at baseline. The lesson: timing is decisive, and the effect lasts only as long as treatment continues.

van Andel E, Bijlenga D, Vogel SWN, et al. Chronobiol Int. 2021;38(2):260-269. doi:10.1080/07420528.2020.1835943 · PMID: 33121289

An important addition comes from the secondary analysis of the same study. van Andel 2022 in Journal of Biological Rhythms showed: although the body clock (DLMO) shifted earlier, actual sleep times did not automatically follow. Melatonin alone did not extend sleep duration. The authors concluded that an accompanying behavioral coaching component is needed so that sleep times follow the shifted clock. Put differently: melatonin opens the window, but you also have to walk through the window.

The systematic review by McDonagh 2019 in Journal of Child Neurology (22 RCTs, 1758 children) puts this into a broader context: across 19 studies melatonin improved sleep-onset latency by a median of about 28 minutes and sleep duration by about 33 minutes, with rare side effects. The effect was largest in neurodevelopmental disorders. Anand 2017 in Paediatric Drugs rated the overall evidence on sleeping aids in children with ADHD as weak but saw improvements with melatonin and clonidine in sleep-onset latency and sleep duration, while zolpidem and guanfacine showed no advantage over placebo.

What Is Often Done Wrong

Myth: more melatonin, taken later, is better. The opposite is true for the use as a zeitgeber. The studies that show a phase shift work with low doses (0.5 mg in the adult study) and a time of intake a few hours before one's own melatonin rise. High doses late at night make you tired but barely shift the clock and may carry over into the next day. Dose and timing belong to an individual, medically planned approach, especially alongside ADHD medication.

Stimulants and Sleep: Timing Counts

Methylphenidate and amphetamines are the most effective medications against the core symptoms of ADHD. Their relationship to sleep is, however, double-edged. Snitselaar 2016 in Journal of Attention Disorders summarized the evidence: stimulants may shift the circadian rhythm further back, that is, additionally delay the already delayed clock. A dose taken too late in the afternoon can make falling asleep harder.

At the same time, many people report that well-adjusted stimulant therapy reduces evening racing thoughts and so, paradoxically, can make falling asleep easier. Both are real and depend on the person, preparation, dose and timing. This is exactly why the time of intake is one of the most important adjustment screws when sleep and ADHD medication collide.

Reframe

When ADHD medication disturbs sleep, the solution is rarely "stop it" and rarely "add a sleeping pill on top." The solution usually lies in timing: tuning the preparation, dose and time of intake so that there is enough effect during the day and enough distance to sleep in the evening. This is fine-tuning and belongs in the hands of the treating physician. Never change existing medication on your own.

Light as the Strongest Zeitgeber

When the body clock runs late, light is the physiologically most obvious tool to pull it forward. Bright light in the morning signals to the brain "the day is starting now" and shifts the clock earlier. Bright light in the evening does the opposite and shifts it further back, which is why screen light late in the evening is particularly unfavorable with a delayed phase.

Study · Pilot Study, Adults

Morning Light Therapy Shifts the Delayed Phase Earlier

Human Rachel Fargason and colleagues studied in 2017 in Journal of Psychiatric Research a morning light therapy in adults with ADHD: for two weeks 30 minutes of 10,000 lux, starting about three hours after the sleep midpoint, in addition to standard treatment. The light shifted the DLMO on average 31 minutes earlier and the sleep midpoint by 57 minutes. Crucially: the phase shift correlated with a decrease in overall ADHD scores and especially the hyperactivity and impulsivity scores. This was a small pilot study, so the results should be interpreted with caution, but they point in a consistent direction with the rest of the literature.

Fargason RE, Fobian AD, Hablitz LM, et al. J Psychiatr Res. 2017;91:105-110. doi:10.1016/j.jpsychires.2017.03.004 · PMID: 28327443

In practice, light can be used in both directions: bright light in the morning (daylight or a light therapy lamp) pulls the clock forward, dimmed light and reduced screen use in the evening prevent a further delay. This combination has few side effects and complements melatonin well, as the van Andel study shows, in which the combination shifted the DLMO the most.

The Vicious Circle: Sleep Loss Amplifies ADHD

One point I emphasize again and again in consultations: sleep loss itself produces symptoms that look deceptively like ADHD. Poor concentration, irritability, impulsivity, daytime sleepiness and emotional instability are classic consequences of too little or poor sleep. In ADHD the two sources overlap.

Study · Meta-Analysis, Adults

Disturbed Sleep Profile in Adults with ADHD

Meta-Analysis Jorge Lugo and colleagues analyzed in 2020 in European Neuropsychopharmacology, in a systematic review with meta-analysis, 42 studies on sleep in adults with ADHD and autism spectrum disorder. For ADHD a consistent pattern emerged compared with healthy controls: longer sleep-onset latency, poorer sleep efficiency, more frequent nighttime awakenings and a generally poorer self-perceived sleep quality. Specific to ADHD were increased periodic limb movements in sleep. The authors emphasize that concomitant medication and psychiatric comorbidities must be controlled for.

Lugo J, Fadeuilhe C, Gisbert L, et al. Eur Neuropsychopharmacol. 2020;38:1-24. doi:10.1016/j.euroneuro.2020.07.004 · PMID: 32712061

From this a circle arises: ADHD delays and destabilizes sleep, the poor sleep amplifies ADHD symptoms the next day, which in turn makes the evening wind-down harder. The good lever on this circle is sleep itself. Those who stabilize the body clock and improve sleep quality often also improve their daytime symptoms. This is not a promise of a cure but a plausible consequence of the body of studies.

The Four KPNI Lenses on ADHD and Sleep

In Clinical Psychoneuroimmunology I look not only at the diagnosis but at the systems behind it. Four lenses help to understand sleep in ADHD and to find points of leverage.

Circadian Lens

The internal pacemaker runs late. Light in the morning, darkness in the evening and a constant wake-up time are the strongest levers to stabilize the clock. Melatonin as a chronobiotic complements but does not replace them.

Neurotransmitter Lens

Dopamine and noradrenaline signals are central in ADHD and in sleep-wake regulation. Stimulants act exactly here, which is why they influence wakefulness and sleep at the same time and why timing is so important.

Stress Axis Lens

A shifted morning cortisol rise accompanies the delayed phase. Evening racing thoughts and tension keep the system awake. Stress regulation and an evening routine act on this axis.

Behavioral Lens

Late screen time, irregular schedules and putting off going to bed (revenge bedtime procrastination) reinforce the biology. This is where the behavioral component comes in, without which, according to van Andel 2022, sleep times do not follow the clock.

What You Can Do Yourself

The following steps have few side effects and form the basis. They do not replace a medical examination, especially if you take medication.

Practical Levers for the Delayed Clock

  1. Light in the morning: several minutes of bright daylight or a light therapy lamp right after getting up. This pulls the body clock forward and stabilizes the rhythm.
  2. Dim the light in the evening: reduce bright light and screens in the last one to two hours before the target sleep time, because evening light pulls the clock back.
  3. Constant wake-up time: get up at roughly the same time every day, including on weekends. Irregular times destabilize the already labile rhythm (Bijlenga 2013).
  4. Caffeine timing: avoid caffeine in the afternoon and evening, since it can measurably worsen falling asleep and sleep quality.
  5. Discuss medication timing: if ADHD medication disturbs sleep, have the timing adjusted medically, do not change it on your own.
  6. Melatonin only with a plan: if melatonin, then in a low dose and a few hours before your own melatonin rise, with medical supervision.
The Core in One Sentence

You are not fighting a lack of discipline but a shifted body clock.

And a shifted clock can be gently reset with light, timing and possibly melatonin. This needs consistency, not willpower in a battle against your own biology.

Safety Note and Limits

This text serves as information and does not replace a medical examination, a diagnosis or individual advice. ADHD and sleep disorders should be assessed by a specialist. Never change existing medication on your own. Melatonin is, depending on dose and country, pharmacy-only or prescription-only and can interact with other medications, especially ADHD medication. With loud snoring with breathing pauses (suspected sleep apnea), with pronounced evening restlessness of the legs (suspected restless legs syndrome) or with persistent daytime sleepiness despite sufficient time in bed, a sleep-medicine evaluation is advisable. The studies referred to here show effects at the group level that may differ in the individual case.

Frequently Asked Questions about ADHD and Sleep

Why do so many adults with ADHD struggle to fall asleep?

Because the body clock runs late in a large proportion of people with ADHD. This is called Delayed Sleep Phase Syndrome (DSPS). The body releases the sleep hormone melatonin later than in people without ADHD. Bijlenga 2013 in Journal of Sleep Research measured a dim-light melatonin onset (DLMO), the evening rise in melatonin, in medication-naive adults with ADHD and delayed sleep that was on average about 1.5 hours later than in healthy controls. van Andel 2021 in Chronobiology International found a DLMO after 9 pm in 77 percent of the adults with ADHD studied, on average at 11:43 pm. When the internal signal to sleep arrives only late, falling asleep before midnight is biologically hard. On top of this comes the racing thoughts in the evening that many people know well. Important: this is a description of patterns from studies, not a substitute for an individual medical evaluation.

Does melatonin help with ADHD-related trouble falling asleep?

Melatonin may help with a delayed body clock, but differently than most people think. It does not work primarily as a sleeping pill but as a chronobiotic that shifts the body clock earlier when taken in a low dose a few hours before one's own melatonin rise. van der Heijden 2007 published in Journal of the American Academy of Child and Adolescent Psychiatry an RCT with 105 children with ADHD and chronic sleep-onset insomnia: melatonin shortened sleep-onset time by about 27 minutes on average and shifted the DLMO about 44 minutes earlier. van Andel 2021 in Chronobiology International showed in adults with ADHD and DSPS: 0.5 mg melatonin, taken three hours before the individual DLMO, shifted the body clock about 1.5 hours earlier and reduced self-reported ADHD symptoms by 14 percent. Important: after discontinuation the values returned to baseline. Melatonin is prescription-only or, depending on dose, pharmacy-only and belongs in medical hands, especially alongside ADHD medication.

Do stimulants such as methylphenidate worsen sleep?

They may worsen sleep, especially when taken later. Snitselaar 2016 summarized the evidence in Journal of Attention Disorders: stimulants may shift the circadian rhythm further back (phase delay). At the same time, some people report that well-adjusted stimulant therapy reduces evening racing thoughts and can thereby make falling asleep easier. Both can be true, depending on the person, dose and timing. In practical terms: the time of intake is an important lever. A dose taken too late in the afternoon can make falling asleep harder. Adjusting the preparation, dose and timing belongs in the hands of the treating physician and should not be changed on one's own.

What is the difference between a delayed body clock and insomnia?

With classic insomnia a person cannot fall asleep at the desired time and also sleeps poorly at other times. With a delayed body clock (Delayed Sleep Phase Syndrome) the sleep itself is often good, just shifted in time: people might fall asleep only at 2 am and would sleep through until 10 am if they could. The problem arises from the conflict with work and social schedules. Snitselaar 2016 in Journal of Attention Disorders describes that the sleep profile of many adults with ADHD matches exactly that of a delayed sleep phase disorder: longer objective sleep-onset latency, shifted wake-up time, pronounced evening type. This distinction is therapeutically decisive, because a delayed clock responds more to light and timing than to classic sleeping pills.

Can light therapy help with ADHD and sleep problems?

Morning bright light may shift the delayed body clock earlier. Fargason 2017 in Journal of Psychiatric Research studied a two-week morning light therapy in adults with ADHD (30 minutes of 10,000 lux, starting about 3 hours after the sleep midpoint). The DLMO shifted on average 31 minutes earlier, the sleep midpoint by 57 minutes. Important: the phase shift correlated with a decrease in ADHD symptoms, especially hyperactivity and impulsivity. This was a small pilot study, so the results should be interpreted cautiously. Light is a strong zeitgeber for the body clock and may be a sensible, low-side-effect building block. A combination of light in the morning and light hygiene in the evening (dimmed light, less screen time) is plausible and well tolerated.

Does poor sleep amplify ADHD symptoms?

Yes, this is a central and often underestimated point. Sleep loss produces symptoms that look very much like ADHD: concentration problems, irritability, impulsivity, daytime sleepiness, emotional instability. Lugo 2020 published in European Neuropsychopharmacology a meta-analysis of 42 studies and found a consistently disturbed sleep profile in adults with ADHD: longer sleep-onset latency, poorer sleep efficiency, more nighttime awakenings and a poorer self-perceived sleep quality compared with healthy controls. This creates a vicious circle: ADHD delays sleep, and poor sleep amplifies ADHD symptoms during the day. This is exactly why sleep in ADHD is not a side issue but its own treatment lever. Those who stabilize their sleep often also improve their daytime symptoms.

Which sleep hygiene measures are especially important in ADHD?

With a delayed body clock the measures that act as zeitgebers count most. First, bright light in the morning, ideally daylight right after getting up, which stabilizes the day-night rhythm. Second, dimmed light and reduced screen use in the last one to two hours before the target sleep time, because bright evening light shifts the body clock further back. Third, wake-up times that are as constant as possible, including on weekends, because irregular times destabilize the already labile rhythm (Bijlenga 2013 in Journal of Sleep Research found markedly more variable bedtimes in ADHD than in controls). Fourth, avoiding caffeine in the afternoon and paying attention to the timing of ADHD medication. These measures do not replace a medical examination but have few side effects and can form the basis of any treatment.

When should I have ADHD and sleep problems medically evaluated?

Whenever sleep clearly impairs daytime functioning, when you take sleeping pills or melatonin on your own on a lasting basis, when you are very overtired during the day despite sufficient time in bed, with loud snoring with breathing pauses (suspected sleep apnea), with pronounced evening restlessness of the legs (suspected restless legs syndrome, which occurs more often in ADHD) or when ADHD medication noticeably worsens your sleep. A suspected delayed sleep phase disorder should also be assessed medically, because treatment with timing, light and possibly melatonin belongs to an individual plan. Important: this text does not replace a medical examination or individual advice. Never change existing medication on your own.

More from the cluster "Treating Sleep Disorders Holistically"

Connections to Other Topics

The Overview of the ClusterTreating Sleep Disorders Holistically

The pillar article puts all sleep topics in context, from the body clock through hormones to sleep hygiene. Here you will find the big picture.

When Melatonin Is the TopicUsing Melatonin Correctly

Dose, timing and the effect as a chronobiotic in detail. Exactly the logic that is decisive in ADHD and a delayed phase.

When the Body Clock Runs LateCircadian Rhythm and the Body Clock

How light, DLMO and sleep phase relate to each other. The foundations on which treatment of the delayed phase in ADHD builds.

When Light Therapy Is of InterestLight as a Zeitgeber

Why morning light shifts the clock forward and evening light shifts it back, and how to use this deliberately.

SJ
Written by

Shukri Jarmoukli

Physician, Integrative Medicine, Clinical Psychoneuroimmunology · ViveCura Berlin, Skalitzer Straße 137 · Focus areas: the delayed body clock (Delayed Sleep Phase Syndrome) as the core of many sleep problems in adults with ADHD, shown via the delayed dim-light melatonin onset in Bijlenga 2013 in Journal of Sleep Research and van Andel 2021 in Chronobiology International, melatonin as a chronobiotic rather than a sleeping pill (van der Heijden 2007 RCT in children, van Andel 2021 RCT in adults, McDonagh 2019 systematic review), the timing of stimulants and their influence on the circadian rhythm according to Snitselaar 2016 in Journal of Attention Disorders, morning light therapy for phase correction according to Fargason 2017 in Journal of Psychiatric Research, and the vicious circle of sleep loss and amplified ADHD symptoms according to Lugo 2020 in European Neuropsychopharmacology. My aspiration is a sleep medicine that first understands the biology and then works with light, timing and behavior before it sedates.

Sources and Further Reading

  1. Bijlenga D, Van Someren EJW, Gruber R, et al. Body temperature, activity and melatonin profiles in adults with attention-deficit/hyperactivity disorder and delayed sleep: a case-control study. J Sleep Res. 2013;22(6):607-16. doi:10.1111/jsr.12075 · PMID: 23952346 [Case-Control]
  2. van Andel E, Bijlenga D, Vogel SWN, Beekman ATF, Kooij JJS. Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: a randomized clinical trial. Chronobiol Int. 2021;38(2):260-269. doi:10.1080/07420528.2020.1835943 · PMID: 33121289 [RCT]
  3. van Andel E, Bijlenga D, Vogel SWN, Beekman ATF, Kooij JJS. Attention-Deficit/Hyperactivity Disorder and Delayed Sleep Phase Syndrome in Adults: A Randomized Clinical Trial on the Effects of Chronotherapy on Sleep. J Biol Rhythms. 2022;37(6):673-689. doi:10.1177/07487304221124659 · PMID: 36181304 [RCT]
  4. Van der Heijden KB, Smits MG, Van Someren EJW, Ridderinkhof KR, Gunning WB. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad Child Adolesc Psychiatry. 2007;46(2):233-41. doi:10.1097/01.chi.0000246055.76167.0d · PMID: 17242627 [RCT]
  5. Snitselaar MA, Smits MG, van der Heijden KB, Spijker J. Sleep and Circadian Rhythmicity in Adult ADHD and the Effect of Stimulants. J Atten Disord. 2017;21(1):14-26. doi:10.1177/1087054713479663 · PMID: 23509113 [Review]
  6. Fargason RE, Fobian AD, Hablitz LM, et al. Correcting delayed circadian phase with bright light therapy predicts improvement in ADHD symptoms: A pilot study. J Psychiatr Res. 2017;91:105-110. doi:10.1016/j.jpsychires.2017.03.004 · PMID: 28327443 [Real-World]
  7. Lugo J, Fadeuilhe C, Gisbert L, et al. Sleep in adults with autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic review and meta-analysis. Eur Neuropsychopharmacol. 2020;38:1-24. doi:10.1016/j.euroneuro.2020.07.004 · PMID: 32712061 [Meta-Analysis]
  8. McDonagh MS, Holmes R, Hsu F. Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review. J Child Neurol. 2019;34(5):237-247. doi:10.1177/0883073818821030 · PMID: 30674203 [Systematic Review]
  9. Anand S, Tong H, Besag FMC, Chan EW, Cortese S, Wong ICK. Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological Quality Assessment. Paediatr Drugs. 2017;19(3):235-250. doi:10.1007/s40272-017-0224-6 · PMID: 28391425 [Systematic Review]
  10. Micic G, de Bruyn A, Lovato N, et al. The endogenous circadian temperature period length (tau) in delayed sleep phase disorder compared to good sleepers. J Sleep Res. 2013;22(6):617-24. doi:10.1111/jsr.12072 · PMID: 23899423 [Case-Control]
Note on the evidence base: The central evidence for a delayed circadian phase in adults with ADHD comes from case-control data (Bijlenga 2013 in Journal of Sleep Research) and the chronotherapy study van Andel 2021 in Chronobiology International. The benefit of low-dose melatonin as a chronobiotic is shown in RCTs (van der Heijden 2007 in children, van Andel 2021 in adults), with van Andel 2022 showing that sleep times follow the shifted clock only with accompanying behavioral coaching and that the effect declines after discontinuation. The systematic reviews McDonagh 2019 and Anand 2017 rate the pediatric evidence on sleeping aids as limited, with the most consistent effects for melatonin. The light therapy evidence (Fargason 2017) comes from a small pilot study and should be interpreted cautiously. Lugo 2020 documents the disturbed sleep profile in adults with ADHD at the meta-analysis level. Snitselaar 2016 places the influence of stimulants on the circadian rhythm in context. Limitations: many studies have small samples, and part of the robust data comes from pediatric populations. This text does not replace a medical examination. Existing medication must never be changed on one's own.

Have questions or want to book an appointment?

We'd be happy to advise you personally at our practice.

Book appointment