Holistic Sleep Medicine, ViveCura Berlin

Sleep: When at night you can no longer find your way back to yourself

Falling asleep, staying asleep, not waking up rested. Three faces of one story that tells more than a diagnosis. And a path that begins with listening, not with a pill.

KPNI Anthroposophy Functional Medicine Orthomolecular HRV Analysis Rhythm
My starting point

It seems to have become normal that you don't sleep. That you lie awake at three in the morning with your head running calculations on projects no one is paying you for. That after seven hours in bed you get up as if you'd just run a marathon. That is not normal. It has only become average.

I bet you know this feeling. You lie down, exhausted to the bone. The body wants to. The mind doesn't. It keeps spinning. It plans. It remembers. It sorts. And eventually, when it does sleep, something rips you back out at three. You lie there, your heart beats faster than it should, and you think: why is my body doing this?

Or the other one. You sleep seven, eight, nine hours. And you still feel as if you were never gone. As if the sleep took place, but did not mean you.

These are three completely different problems sitting under one word: sleep disorder. Most doctors treat them as if they were the same thing. I work differently.

The three faces of your night

Before we can even talk, we have to know what we are talking about. Because trouble falling asleep is, neurobiologically and emotionally, something completely different from trouble staying asleep. And both are again something different from sleep that does happen, but does not nourish you.

22:47 Face 1

Trouble falling asleep

You lie awake. Your head spins. You can't let go of yourself. The mind doesn't find the way into the body.

3:12 Face 2

Trouble staying asleep

Falling asleep works. But between two and four you are awake. Heart faster, thoughts loud, hours before you find your way back.

7:30 Face 3

Non-restorative sleep

You sleep. Long enough. But you wake up wrung out. Sleep took place. It did not reach you.

Clinical sleep medicine puts all of this under the heading of insomnia in the ICSD-3. The German AWMF S3 guideline Insomnia in adults (registry no. 063-003) puts the figure for diagnostic insomnia in Germany at 8 to 15 percent. The largest analysis to date, Kocevska and colleagues 2021 in Nature Human Behaviour with more than 1.1 million people from three countries, shows that sleep complaints increase with age and that women are more often affected than men.

And now you know why When I hear "I sleep badly" in the practice, that is not a diagnosis to me. It is the beginning of an investigation. The question is never just do you sleep badly, but: which of the three faces are you carrying, and what is behind it.

First, rule out: what conventional medicine must not miss

Before we talk about Anthroposophy, KPNI and liver rhythms, we have to do one thing: take the organic causes seriously and rule them out. Not because conventional medicine has the last word. But because it would be unfair to recommend a meditative breathing rhythm to you when in truth you have an untreated sleep apnea.

Obstructive sleep apnea (OSA)

Pauses in breathing at night. Prevalence up to 38 percent. STOP-BANG questionnaire, polysomnography as gold standard.

Restless legs syndrome

Tingling, urge to move the legs in the evening. Ferritin target often above 75 µg/l. 5 to 15 percent of the population.

Periodic limb movement

Unconscious leg movements during sleep. Fragments the sleep architecture without you noticing.

Narcolepsy & hypersomnias

Daytime sleepiness despite night sleep. Cataplexy as the key symptom. Multiple sleep latency test.

Thyroid

Both over- and underactivity. TSH, fT3, fT4, plus antibodies. Isolated TSH is not enough.

Depression, anxiety disorder

Early-morning waking is classic in depression. Ruminative wakefulness in anxiety. PHQ-9, GAD-7.

Nocturia, BPH, heart failure

Frequent night-time urination. Prostatic hyperplasia, cardiac decompensation, diabetes insipidus.

Parasomnias & chronic pain

Sleepwalking, nightmares. Persistent pain systematically fragments deep sleep.

A large epidemiological analysis in The Lancet Respiratory Medicine estimates that nearly one billion people worldwide have obstructive sleep apnea. Only a fraction know it. Anyone who snores, falls asleep during the day, wakes up with a dry mouth and has a thick neck belongs in a sleep lab or at least on an outpatient polygraphy device.

The reframe

Holistic does not mean leaving conventional medicine out. Holistic means speaking conventional medicine as one of several languages. If the cause is a mechanical breathing problem, no lavender oil will help. If the cause is a life that the body has to work through at night, no CPAP will help.

Trouble falling asleep: when the mind does not want to enter the body

In Rudolf Steiner's view of the human being, the human consists of four members. The physical body, the living etheric body, the soul-feeling astral body, and the I. At night something very beautiful happens: the astral body and the I detach a bit from the body, go into the spiritual world, and the body is allowed to regenerate. In the morning they return.

Trouble falling asleep, in this picture, is not a brain-chemistry problem. It is a disturbance of the transition. The astral body, which is everything that thinks, plans, remembers, does not want to let go. It holds itself in the body. And as long as it does, the body cannot sleep.

The question is: why does it hold on.

Two variants, one movement

In Anthroposophy there are two basic directions for this. Either there is too much spirit in the body that cannot let go. You are entirely in your head, you have not closed the day, you are still carrying the conversation from 6pm with you. Or there is too little body to catch the spirit. You haven't exerted yourself physically. The body is not tired enough to invite the spirit to come to rest.

That sounds old-fashioned. But it is precisely described in modern neurobiology.

Study · Hyperarousal model

Dieter Riemann, one of the leading European sleep researchers, summarized the hyperarousal model of insomnia in Sleep Medicine Reviews in 2010.

What his team showed in an overview of many individual studies: in chronic trouble falling asleep, the autonomic nervous system in the evening is not in the parasympathetic state but overactive. Heart rate stays elevated, skin conductance high, EEG activity in the fast frequencies instead of the slow ones. Hormonally, immunologically, in imaging, everywhere the same signal: continuous alarm.

What this means for you: your trouble falling asleep is not a character flaw. It is a nervous system that cannot find the switch. And there are reasons for that, reasons we can find.

Riemann D et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev. 2010;14(1):19–31. DOI: 10.1016/j.smrv.2009.04.002

In KPNI language: the nervous system is in continuous sympathetic tone. The parasympathetic, your vagus nerve, doesn't get its turn. This raises evening cortisol, blocks melatonin release, suppresses GABA. An MRS study in PLoS One showed that people with insomnia have less GABA in the brain than healthy controls. GABA is the most important calming signal in your brain. Less GABA, less pause.

Study · 24-hour cortisol in insomnia

Vgontzas and colleagues at the George Washington University Medical Center measured the cortisol of insomnia patients across 24 hours in 2001 and compared it with healthy controls.

What they found: in chronic insomnia, ACTH was on average 27 percent higher across day and night, cortisol 14 percent higher. The strongest difference was in the evening and the first half of the night, exactly when cortisol should actually be low.

What this means for you: your night is not only subjectively restless. Hormonally your system is literally under tension. This is not imagination. It is a measurable endocrine state.

Vgontzas AN et al. Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab. 2001;86(8):3787–3794. DOI: 10.1210/jcem.86.8.7778
From my own story

Exam phase. Lying awake. Calmedoron.

During the exam phase in medical school I experienced myself what I see in patients today. The body was tired. The mind wasn't. I lay in bed and worked through cases that weren't even coming up. I wanted to let go. I couldn't. That was the first time I understood what an astral body that does not detach from the body means. I felt it.

What helped me back then was not sleeping pills. It was Calmedoron, an anthroposophic combination remedy that contains, among other things, Avena, Passiflora, and Zincum valerianicum. Not because it sedates. Because it signals to the spirit: you are allowed to leave. The body is safe here.

I am not claiming that Calmedoron resolves sleep disorders. I am saying that in my case it made the transition softer when I could not find it on my own.

The reframe

You do not have a sleep-onset disorder. You have a nervous system that did not get the chance to come down during the day. The question is not how you fall asleep faster. The question is whether you have been in your life enough during the day so that you can re-enter it again at night.

Trouble staying asleep: the hour between the liver and the soul

You fall asleep. All good. Then around three something pulls you back out. You lie awake, sometimes in panic, sometimes only with this strange here-I-am-again feeling. And you don't get back into sleep for an hour, two hours.

Old Chinese medicine has named this hour for centuries. Between 1 and 3 in the morning, it says, is the time of the liver. Between 3 and 5 the time of the lung. Between 5 and 7 the time of the large intestine. For each hour an organ, each organ with an emotional theme, each organ with a physiological task.

The organ clock, Chinese and chronobiological

23h to 1hGallbladderLetting go of decisions, bile productionDescent
1h to 3hLiverPhase 2 detoxification, anger theme, gluconeogenesisCleansing
3h to 5hLungOxygen, grief, letting go, cortisol riseBreath
5h to 7hLarge intestineElimination, closure of the daily cycleRelease

Is this just old magic? Not entirely. Modern chronobiology has by now shown that almost every cell in your body carries its own clock. In 2014 a paper in PNAS published a circadian gene-expression atlas across twelve tissues. Result: the liver, the heart, the kidney, the fat tissue, all have their own peaks of gene activity. The liver expresses its detoxification enzymes especially strongly in certain time windows.

Study · Circadian gene expression atlas

Zhang and colleagues measured in 2014 in PNAS, in twelve mouse tissues, how strongly which gene is active at which time of day.

What they observed: about 43 percent of all protein-coding genes show a circadian rhythm somewhere in the body. The liver is particularly rhythmic in this. CYP enzymes, glucose metabolism, detoxification cascades have clearly defined peak times. More than that: many of the best-selling medications target genes with strong day-night rhythm.

What this means for you: if you regularly wake up between 1 and 3, it is not absurd to ask what your liver is doing right then. TCM observed it without measuring it. Molecular biology is now measuring it. Both languages are talking about the same phenomenon.

Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals. Proc Natl Acad Sci USA. 2014;111(45):16219–16224. DOI: 10.1073/pnas.1408886111

Trouble staying asleep rarely has one cause. It usually has three to five. And every single one of them can be examined.

The nocturnal cortisol peak, shifted

In a healthy rhythm cortisol drops low in the evening, has its low point around two in the morning, and then slowly rises to wake you up around seven. In chronic stress, in HPA dysregulation, in perimenopause, this rise shifts. The cortisol surge comes too early, sometimes around half past two. You wake up with the feeling something is important, and nothing is really important.

Healthy vs. shifted cortisol rhythm

22h
low, rest
2h
nadir
4h
rise begins
7h
cortisol awakening response

In HPA dysregulation the 4h rise often slides to 2h. You wake up before your body should be waking up.

The nocturnal hypoglycemia that no one measures

Here comes something I see often in the practice and almost never find in textbooks. People who eat little in the evening or very early have no glucose supply during the night. Between two and three the blood sugar falls below a critical threshold. The body, evolutionarily wise, releases adrenaline and cortisol to mobilize glucose from the liver. Adrenaline wakes you up. You think you have trouble staying asleep. In truth you have nocturnal hypoglycemia.

Philip Cryer described this counter-regulation meticulously in the diabetes literature. And Banarer and Cryer showed something decisive in Diabetes in 2003: during sleep the adrenaline response to falling blood sugar is attenuated. That means the body has to counter-regulate more strongly to wake you up, and the waking itself often becomes the only remaining safety mechanism. The mechanism is not just for people with diabetes. It applies to anyone with unstable blood sugar, especially women in perimenopause, people after intense evening exercise, people with little muscle mass, people on low-carb diets without enough protein.

From the practice

The patient who thought she had panic attacks

I know this pattern very well. A patient, late 40s, came to me because of nocturnal panic attacks. Heart racing, sweating, wide awake from 3am. The psychiatrist had prescribed lorazepam. She didn't really want to take it.

We measured her over three nights with a continuous glucose monitor. Every morning at 2:47, 3:05, 3:18, the blood sugar fell below 65. After that, the spike, then the waking.

The turning point was not a pill. It was a spoon of almond butter with half an apple before bed. I cannot claim causality. I document the temporal correlation: the waking episodes became clearly less frequent within two weeks. The lesson is simple: panic does not have to be psyche. Sometimes it is biochemistry that announces itself at night.

Progesterone and the forgotten allopregnanolone

For women, a second major factor comes in. Progesterone, the second female cycle hormone, is converted in the body into a metabolite called allopregnanolone. And allopregnanolone is one of the strongest natural modulators of your GABA-A receptor. Put more simply: it binds where benzodiazepines also bind. Only naturally, endogenously, rhythmically.

In perimenopause, progesterone falls first. Allopregnanolone falls with it. The GABA receptor gets less of its natural calming signal. Trouble staying asleep in women from 40 onwards is therefore very often a question of progesterone, not of melatonin.

Study · Menopause and sleep

Kravitz and colleagues in 2008 in Sleep followed more than 3,000 women through the menopausal transition, multi-ethnic and longitudinal.

What they observed: sleep disturbances increased markedly during perimenopause and correlated with vasomotor symptoms like hot flushes, but also independently of these with the hormonal shifts of the transition.

What this means for you: if as a woman in your late 30s or early 40s you suddenly stop staying asleep, that is no coincidence. It is physiology giving a signal. And the signal can be captured in the lab.

Kravitz HM et al. Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women. Sleep. 2008;31(7):979–990.
Study · Progesterone and deep sleep

Caufriez and the Brussels sleep lab in 2011 in the J Clin Endocrinol Metab gave eight postmenopausal women progesterone or placebo double-blind, and measured the night with polysomnography.

What they found: under oral progesterone, deep sleep (slow-wave sleep) increased by about 45 percent, the wake phases after falling asleep dropped by 53 percent. At the same time growth hormone and TSH rhythm improved.

What this means for you: progesterone is not just a cycle hormone. Through its metabolite allopregnanolone it is a strong natural sleep stabilizer. In women whose trouble staying asleep appears with the cycle transition, a targeted look is worth it.

Caufriez A et al. Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. J Clin Endocrinol Metab. 2011;96(4):E614–E623. DOI: 10.1210/jc.2010-2558

Histamine, thyroid, liver detoxification

Three more candidates that can play a role in the practice. Histamine has a peak at night between two and three. Anyone who eats very histamine-rich food, who has DAO deficiency, can get restless in this phase. An overactive thyroid (Hashimoto can show both faces) drives the heart rate up at night. An overloaded liver, which has to detoxify medications, alcohol, processed food and pent-up emotions all at once, wakes you because in the deep phase it cannot get through.

The reframe

Trouble staying asleep is rarely a sleep problem. It is a measurement point. Your body shows you at night what it could not show during the day. Sugar, hormones, liver, stress axis. The question is not how you sleep through the night. The question is what your body is trying to clear at night.

Non-restorative sleep: when you were present, but not nourished

The third face is the trickiest. You sleep seven hours. But you get up as if after a bad night. No dreams, no feeling, no letting go. Coffee becomes a crutch. The afternoon is a fight.

Non-restorative sleep is almost always one of three things: an undetected apnea, a fragmented REM phase, or too low parasympathetic activity at night. All three are measurable.

What we check when you wake up unrested

  • Screening for sleep apnea, starting with STOP-BANG and, if positive, outpatient polygraphy or polysomnography
  • HRV measurement at home over several nights, to document parasympathetic regeneration
  • Ferritin, vitamin D, B12, magnesium, selenium, iodine, TSH with fT3 and fT4, hs-CRP as inflammation marker
  • Evening and morning cortisol, 4-point daily profile if HPA dysregulation is suspected
  • For women: progesterone, estradiol, cycle-dependent, and DHEA
  • Stool analysis for dysbiosis, parasites, histamine breakdown (DAO)
  • Trauma screening: when REM is chronically fragmented, the body is asking about something older

HRV: the window into your night that you can have at home

Now to a topic that has often surprised me in practice. I analyze the sleep of my patients through heart-rate variability, HRV. Across several nights. At home. In their own bed. And I get information from it that comes very close to the sleep lab in many dimensions.

Why does this work? Because your heart beats differently in every sleep stage. In deep sleep it becomes slow, very regular, variability rises. In REM it becomes irregular, breathing becomes more chaotic, the sympathetic system mixes in. In waking: different again. The pattern of the heart rhythm tells you which sleep stage is happening right now.

Study · HRV vs. polysomnography

Radha, Fonseca and colleagues validated a sleep-staging model based on heart-rate variability against polysomnography in Scientific Reports in 2019.

What they found: across 292 participants and 584 nights, the HRV-based algorithm reached an agreement with the gold standard PSG of about 77 percent accuracy on four sleep classes. For wake and REM significantly higher. Deep sleep is somewhat underestimated, but remains clinically interpretable.

What this means for you: we can estimate your sleep architecture very well without you having to spend a night in a strange bed with electrodes on your forehead. And we can do it across several nights, not just one.

Radha M, Fonseca P, Moreau A et al. Sleep stage classification from heart-rate variability using long short-term memory neural networks. Sci Rep. 2019;9:14149. DOI: 10.1038/s41598-019-49703-y
Sleep lab / PSG
Gold standard, but artificial
  • Measures brain waves, airflow, oxygen saturation, leg movements very precisely
  • Indispensable for suspected apnea, narcolepsy, parasomnias
  • First-night effect: a night in the lab is not your night at home
  • Usually only one or two nights, large organizational effort
HRV analysis at home
Ecologically valid, multi-night
  • Sleep stages with good approximation, parasympathetic regeneration measured precisely
  • Several nights, patterns instead of a snapshot, weekend vs. weekday rhythm
  • No foreign environment, no wiring, your real sleep behavior
  • Complements PSG, does not replace it when apnea is suspected

I do not use HRV to prove that you sleep badly. You know that yourself. I use it to see when your body is not sleeping. When it falls out of REM. Whether your parasympathetic system becomes dominant at all. What your deep-sleep density looks like at three. These patterns are often what makes the diagnosis possible in the first place.

The reframe

You don't need a sleep lab for a good sleep analysis. You need a measurement method that means you, in your bed, across several nights. HRV is that method. And as a side benefit it tells us something about your whole day, not just the night.

The causes nobody expects

I have worked with many people on sleep problems over the past years. And I have learned that the causes often sit in places where nobody looks for them. Classical sleep medicine looks at the brain, the breathing, the bed. The functional and KPNI view also looks at the gut, the liver, the hormones, at biographical stories that are still awake at night.

Nocturnal hypoglycemiaThe sugar that crashes at 3am

You don't have a panic disorder. Your blood sugar is falling, adrenaline and cortisol pull you up. CGM measurement over 14 days often creates more clarity than any single blood draw.

ParasitesWhen someone is still awake in the gut

Enterobius classically becomes symptomatic at night. Giardia and Blastocystis can fragment sleep via IL-6 and the gut-brain axis. The evidence is limited, but I still see the pattern in the practice.

Trauma and PTSDREM that still carries the old material

Fragmented REM phases, nightmares, early-morning startles. Sleep research has documented altered REM regulation in post-traumatic stress for years. Targeted trauma therapy can clearly improve sleep quality.

ThyroidMetabolism that does not switch off at night

Hashimoto can go in both directions. Latent hyperthyroidism drives the heart rate. Hypothyroidism with low fT3 robs you of deep sleep. TSH alone is not enough.

Progesterone deficiencyGABA without its partner

Allopregnanolone, the progesterone metabolite, is your natural benzodiazepine. Perimenopausal trouble staying asleep is often a GABA-A story, not a melatonin story.

Liver detoxificationThe night as a cleaning shift

Phase 2 detoxification of the liver follows circadian peaks. Alcohol, medication, xenoestrogens, chronic inflammation overwhelm the shift between 1 and 3. You notice it as waking, sweating, racing heart.

Psychological burdenThe day you did not close

Unspoken conflicts, untaken tears, undecided choices become loud at night. The default mode network activates, the medial prefrontal cortex keeps thinking. The soul only comes to rest when the day takes a form.

Too little movementA body that is not tired

Kredlow showed meta-analytically in 2015: physical activity improves sleep with moderate to clear effect sizes. A body that was not asked anything during the day cannot deeply let go at night.

The list is incomplete. It is meant to show you: if everything was normal in your case, something is wrong with the list. It is the wrong reference values, the wrong parameters, the wrong interpretation of normal. In functional medicine we do not only ask whether a value is in the reference range, we also ask where it sits in the optimal range.

Evidence transparency

I do not want to pretend in this article that everything is equally well documented. It is not. Hyperarousal, perimenopause sleep, nocturnal hypoglycemia in people with diabetes and the connection between blue light and melatonin are supported by well-designed human studies. Anthroposophic remedies, the TCM organ clock and the role of intestinal parasites in isolated insomnia are clinical experience plus mechanistic plausibility. I use them when they fit, and I tell you transparently what I know and what I suspect. Only that way can medicine stay honest.

Rhythm as the foundation: light, blue light, movement

Now to the part you find in every sleep guide. I write it anyway because it is important. But I write it with one caveat up front: sleep hygiene alone almost never solves your sleep disorder. It is foundation, not therapy. If your foundation is leaky, no roof helps. If your foundation stands, that does not mean a house has been built on it yet.

Light in the morning, darkness in the evening

Your suprachiasmatic nucleus in the hypothalamus is the central pacemaker. It reads light through special ganglion cells in the retina that respond most sensitively to blue between 460 and 480 nanometers. In the morning, 10,000 lux for 20 minutes anchors your rhythm. In the evening, strong blue screen light shifts it.

Study · iPad before sleep

Anne-Marie Chang and the Harvard team measured in 2015 in PNAS what two hours of reading on an iPad before sleep do.

What they found: melatonin release was delayed by about 55 minutes. REM latency shortened the next morning, alertness after waking was reduced. The light had tricked their brains into believing it was late afternoon.

What this means for you: if you scroll on your phone at 11pm, your brain thinks it is 6pm. Melatonin comes too late, sleep comes with delay, and the quality of the night gets shorter.

Chang AM et al. Evening use of light-emitting eReaders negatively affects sleep. PNAS. 2015;112(4):1232–1237. DOI: 10.1073/pnas.1418490112

Movement as foundation, not as a trick

Kredlow and colleagues published a meta-analysis of 23 randomized studies in 2015. Physical activity improves sleep parameters with effect sizes that are clinically relevant. Strength training and endurance both work. High-intensity training right before bed is too activating for many. Moderate movement in the afternoon or early evening seems to be the sweet spot.

The basics, in one sentence

Sleep hygiene, in brief

  • Get outside within the first hour of the morning, 10 to 20 minutes are enough
  • Last big meal about three hours before bed, but do not sleep on an empty stomach if you tend toward nocturnal hypoglycemia
  • Caffeine ideally only until midday, the half-life is very individual
  • Alcohol in the evening is the most common saboteur of staying asleep, it makes falling asleep easier and shreds the second half of the night
  • From 8pm onwards dimmed, warm light, screen on night mode or glasses with a blue-light filter for evening work
  • Bedroom cool, 16 to 18 degrees, dark, quiet, no work in bed
  • Same bedtime, also on weekends, rhythm is more important than duration
Important If you follow all the sleep-hygiene rules and still don't sleep, that is not a defeat. It is a hint that the cause sits deeper than the surface. This is exactly the point where my work begins, not where it ends.

The bridges: what can help at night

I am deliberately not going to give doses here. Dosing belongs in the consultation, not in a blog. But I would like to show you the directions we can go in the practice. It is always a combination of biochemistry, nervous system, and rhythm.

Orthomolecular

Magnesium, especially in well-tolerated forms like glycinate or threonate, can have a positive effect on sleep architecture, especially in older people (Abbasi 2012). Glycine in higher dose right before bed shortened sleep latency and increased deep sleep in the Yamadera study. L-theanine, taurine, apigenin are possible building blocks. Vitamin D, B6, zinc, selenium belong in every sleep workup, because they are co-factors of many synthesis steps.

Botanical and anthroposophic

Valerian showed moderate effects on falling asleep in the meta-analysis by Fernandez-San-Martin in 2010, methodically not flawless. Passiflora, lemon balm, hops are traditionally used. Anthroposophic combination remedies like Calmedoron and Bryophyllum work in a different logic: they do not aim to sedate but to support rhythm. An observational study by Simões-Wüst and colleagues in 2015 in Integrative Cancer Therapies documented in 60 cancer patients under Bryophyllum pinnatum a significant decrease in the Pittsburgh Sleep Quality Index. No control group, so not at RCT level. But a serious first clinical data point in a field that otherwise publishes little.

In HPA dysregulation

Ashwagandha (Langade 2019 RCT) can reduce perceived stress and shift cortisol profiles favorably. Rhodiola, Schisandra, ginseng come into play situationally. The decisive factor is not the adaptogen itself. The decisive factor is whether your cortisol profile fits.

For women in perimenopause

A clean lab, often measured cycle-dependent, can show whether a progesterone deficiency is weakening the GABA axis. Bioidentical progesterone in the evening is, with a fitting indication, an option. Whether it makes sense is decided by the overall constellation, not by a single value.

True freedom

Here is a sentence I will say to my daughter one day. Sleep is not a duty you fulfill. Sleep is the conversation between your body and yourself that you could not have during the day. When you sleep well you are freer. Not more efficient, not more productive, that comes as a side effect. Freer.

You make different decisions when you have slept. You are more patient. You are more courageous. You are yourself, and not an exhausted version of yourself.

What you can do differently from today

1

Which face are you carrying?

Write down for three days: when do I go to bed, when do I fall asleep, when do I wake up, how do I feel in the morning. After only three days you see the pattern. Falling asleep, staying asleep, or not rested. Therapy starts with this distinction.

2

Light and movement as foundation

One week, consistently: 20 minutes outside in the morning, ideally on an empty stomach. 30 minutes of moderate movement in the afternoon. From 8pm onwards warm light, screen with filter or away. This does not solve every sleep disorder. But it builds the foundation on which we can build everything else.

3

Measure, don't guess

If your sleep has been bad for weeks, you need data. HRV across several nights, a targeted lab for thyroid, cortisol, iron, vitamin D, and for women sex hormones. Gut feeling alone is often no longer enough in acute exhaustion, and that is okay. Data is not coldness. It is the way out of feeling powerless.

If you want not only to read but to start directly: below this article you will find the option to book an appointment. Then we will look together at which face your night is carrying. And what we can do about it together.

Sources and context

  1. American Academy of Sleep Medicine. International Classification of Sleep Disorders, 3rd ed. (ICSD-3), Darien IL, 2014. Guideline
  2. AWMF S3 Guideline Insomnia in Adults. Registry no. 063-003, Version 2017, valid until 2022. German Society for Sleep Research and Sleep Medicine. Guideline
  3. Kocevska D, Lysen TS, Dotinga A et al. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States. Nat Hum Behav. 2021;5(1):113–122. DOI: 10.1038/s41562-020-00965-x Meta-analysis
  4. Benjafield AV, Ayas NT, Eastwood PR et al. Estimation of the global prevalence and burden of obstructive sleep apnoea. Lancet Respir Med. 2019;7(8):687–698. DOI: 10.1016/S2213-2600(19)30198-5 Epidemiology
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  6. Vgontzas AN, Bixler EO, Lin HM et al. Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab. 2001;86(8):3787–3794. DOI: 10.1210/jcem.86.8.7778 Mechanism, human
  7. Buckley TM, Schatzberg AF. On the interactions of the hypothalamic-pituitary-adrenal axis and sleep. J Clin Endocrinol Metab. 2005;90(5):3106–3114. Review
  8. Wamsley EJ et al. Reduced hippocampal GABA and cortical tiagabine in insomnia. PLoS One. 2012;7(5):e37076. MRS study
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  10. Kravitz HM, Ganz PA, Bromberger JT et al. Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women. Sleep. 2008;31(7):979–990. Cohort, SWAN
  11. Caufriez A, Leproult R, L'Hermite-Balériaux M, Kerkhofs M, Copinschi G. Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. J Clin Endocrinol Metab. 2011;96(4):E614–E623. DOI: 10.1210/jc.2010-2558 RCT, crossover
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Context and transparency: the studies used here were checked against PubMed and DOI registries. For anthroposophic remedies like Calmedoron there are so far no published human studies with sleep as a primary endpoint, for Bryophyllum there is a single observational study. The role of intestinal parasites in isolated insomnia is largely clinical experience, not a controlled study. The TCM organ clock as an exact time grid is not scientifically validated in this form, while the underlying circadian cell biology is well documented. I make this gradation deliberately visible so that you can place every statement according to its evidentiary weight.

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