Ginger: more than a tea for colds
What studies show about the medicinal plant, what is only tradition and when caution applies. Well studied for nausea, barely studied for colds: the pungent root, sorted by evidence.
Ginger sits in almost every kitchen. Yet its most famous use, hot tea for a cold, has barely been studied clinically. Here the best known use is the least supported, and the lesser known ones are in part considerably better supported.
Your nose is running. You stand in the kitchen, grate a root into hot water, and the sharp steam rises into your eyes. For many people, that smells like childhood.
In the chilled aisle, small bottles of ginger shots glow on the shelf. The label says something about the immune system. Videos claim the root lowers blood pressure, blood sugar and belly fat.
Many people know this ritual. And the question behind it: what of this is study, what is experience, what is advertising? That is exactly what I sort out here, along with the question of when a pungent root stops being harmless.
When it is not ginger you need, but medical help
- In pregnancy: you can barely keep anything down, can hardly drink, are losing weight, have dark urine, dizziness or blood in your vomit. This needs medical assessment. It may be hyperemesis gravidarum, and there is tested treatment for it.
- Nausea with chest pain, shortness of breath or cold sweat: call the emergency number 112 (Germany and the EU). This is not a moment to wait with home remedies.
- Severe pain in the right upper abdomen, fever, or yellow skin and eyes: get medical assessment immediately, outside office hours in the emergency department. This may be biliary colic or an infection of the bile ducts.
- On anticoagulants: black stools, blood in your vomit, unusual bruising or nosebleeds that won't stop. Get medical help immediately.
- Sudden, worst-ever headache, new paralysis, speech problems, or fever with a stiff neck: call the emergency number 112.
- Joint pain with swelling, redness or fever needs a medical examination. The EU monograph on ginger says so as well.
- Nausea and vomiting during chemotherapy always belong with the oncology team. Ginger is at most an addition there, never a replacement.
Do not stop, reduce or replace any prescribed medication with ginger because of this article. This applies to anticoagulants and antiplatelet drugs, blood pressure medication, diabetes medication, statins and other lipid-lowering drugs, migraine medication and migraine prophylaxis, painkillers for period pain, acid blockers, and medication against nausea in pregnancy or during chemotherapy.
If you take such medication and plan to use ginger in larger amounts, as a capsule, extract or daily shot, discuss this with the prescribing practice first. In pregnancy, one more point applies: before you use ginger specifically against nausea, whether as a preparation, capsule, shot or in larger amounts as tea, talk to your gynaecologist.
Four levels I keep separate in this article
- Supported by RCTs and meta-analyses
- Nausea in pregnancy, above all the feeling of nausea, although the HMPC rates the quality of these studies as low. A small effect on osteoarthritis pain.
- Mechanistically plausible, human studies thin
- Anti-inflammatory action via immune cells, inhibition of serotonin receptors, more testosterone: mostly cell culture and animal experiments.
- Clinical tradition without a strong study base
- Tea for colds, ginger compresses, ginger footbaths.
- What I observe clinically
- I deliberately do not describe effects from my practice here. My stance: when I ask about medication, I also ask about capsules, powders and shots, because plant-based preparations otherwise easily slip out of view.
Gingerol, shogaol and what heat does to the root
Freshly grated ginger burns differently from the powder in the jar. Brighter, lemony, almost piercing. The powder tastes deeper and warmer. Is that just flavour?
Above all, it is chemistry. The rootstock, the rhizome, contains pungent phenols, first and foremost gingerols and shogaols. Picture fresh root and powder like grape and raisin: same origin, different chemistry.
A team around Semwal compiled what is known about the biosynthesis, chemistry and pharmacology of these pungent compounds.
Gingerols are the most important pungent compounds in the fresh rhizome. They are heat sensitive and readily lose water during drying and heating. This produces shogaols, which give dried ginger its typical pungency.
What this means for you: fresh and dried ginger are not chemically the same. The long lists of effects in such reviews, however, rest mostly on laboratory and animal data.
Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Phytochemistry. 2015;117:554-568. PMID: 26228533 · DOI: 10.1016/j.phytochem.2015.07.012 [Review, chemistry]A team around Zick gave 27 healthy volunteers a single dose of ginger in amounts between 100 mg and 2.0 g and took blood samples for up to 72 hours.
In no one could free gingerols or free 6-shogaol be detected, only bound forms, mainly so-called glucuronides, and above 1.0 g also sulfate conjugates of 6-gingerol. The half-lives were under 2 hours.
What this means for you: what meets cells as free gingerol in cell culture does not arrive in the blood in that form. Cell data therefore cannot simply be transferred to humans.
Zick SM, Djuric Z, Ruffin MT, et al. Cancer Epidemiol Biomarkers Prev. 2008;17(8):1930-6. PMID: 18708382 · DOI: 10.1158/1055-9965.EPI-07-2934 [Human study, pharmacokinetics, n=27]You may know this pattern from turmeric. There too, little of the free active compound reaches the blood. How big this hurdle is, I explain in Curcumin and the question of absorption.
Three lenses on the same root
- Nerves. In the lab, ginger extracts, 6-gingerol and 6-shogaol inhibited human 5-HT3 receptors, in cells and in tissue from the nerve network of the gut wall. Classic anti-nausea drugs act on these same serotonin receptors. Lab
- Immune system. In numerous cell and animal studies, ginger phenols influenced macrophages, neutrophils, dendritic cells and T cells. According to a 2024 review, the mechanism is not yet fully understood. Cell and animal
- Stomach. What has been measured in humans is above all faster gastric emptying. More on this in the section on the stomach. Human
A hypothesis from the perspective of Clinical Psychoneuroimmunology: because hardly any free active compounds reach the blood, part of what happens could take place directly in the gastrointestinal tract. This is a conjecture, not a finding. Sources: Walstab 2013, Pázmándi 2024.
Dried is not weaker, and fresh is not stronger. Chemically, the two are different. No one has yet compared them clinically in humans.
And now you know why the same spice tastes different in tea than from the jar, and why no statement about effects follows from that yet.
Well-established or traditional: what the medicines regulators say
A pack says: traditionally used. Does that mean it does nothing?
The answer is in the EU monograph of the HMPC, the Committee on Herbal Medicinal Products at the European Medicines Agency. The revised version for ginger was adopted on 7 May 2025. It separates two categories.
Well-established use
Medically established use. It rests on clinical studies plus at least ten years of use in the EU. For ginger there is exactly one: the prevention of nausea and vomiting in motion sickness.
Traditional use
Traditional use, according to the monograph based exclusively on long-standing use. Plausibility and safety are assessed; proof of efficacy through studies is not required.
The monograph lists five areas as traditional uses: relief of motion sickness, mild cramp-like gastrointestinal complaints with bloating, temporary loss of appetite, mild joint pain and, since the revision, relief of cold symptoms. It also names limits. If gastrointestinal complaints or loss of appetite last longer than two weeks, joint complaints longer than four weeks, or cold symptoms longer than one week, this needs medical assessment.
One detail is surprising. Even for motion sickness, the HMPC in its assessment report rates the quality of the studies and the clinical relevance of the results as low, measured against today's requirements. By its own account, the classification as well-established remains for reasons of regulatory consistency.
In March 2019, an interested party applied, with 136 literature references, to add the relief of pregnancy nausea as a well-established medical use.
The outcome: for mild nausea and mild vomiting in early pregnancy up to week 16, a pivotal study was missing. The five placebo-controlled studies with ginger powder had methodological problems and were of low quality.
What this means for you: for a medicinal indication, the data were not enough for the EU assessors. That is a strict bar, not a statement that ginger does nothing in pregnancy.
HMPC, European Medicines Agency. Assessment report on Zingiber officinale Roscoe, rhizoma. Final, Revision 1. EMA/HMPC/765220/2022. 07.05.2025 [Regulatory document, assessment report]And there is the German predecessor. Commission E at the former Federal Health Office assessed ginger in 1988, with corrections in 1990. According to Commission E, the indications are dyspeptic complaints and the prevention of motion sickness symptoms. According to consistent secondary sources, ginger should be avoided for pregnancy nausea, and used for gallstone disease only after consulting a doctor. The original text was not accessible, hence this caveat.
| Use | EU monograph 2025 | Commission E | Evidence in this article |
|---|---|---|---|
| Motion sickness, prevention | well-established use, study quality low according to HMPC | prevention of symptoms | old, small, contradictory |
| Mild gastrointestinal complaints with bloating | traditional use | dyspeptic complaints | faster gastric emptying, no difference in complaints |
| Temporary loss of appetite | traditional use | not listed as an indication | not evaluated separately here |
| Mild joint pain | traditional use | not listed as an indication | small effect in osteoarthritis, dissenting views |
| Cold symptoms | traditional use, since 2025 | not listed as an indication | no clinical study found |
| Pregnancy nausea | not included, use best avoided as a precaution | not recommended according to secondary sources | nausea better, vomiting not significant |
Traditional is like a family recipe, tried over generations and checked for safety. It is not proof from studies.
So traditional does not mean ineffective. It means: the experience is old, the proof is still pending.
And now you know why tea for colds is a tradition and motion sickness is a question for studies.
Ginger for nausea: pregnancy, surgery, chemotherapy, travel
Your stomach is turning, and someone hands you a ginger sweet. Does that do anything?
Nausea is the field in which ginger has been studied most often. A large overview of 24 systematic reviews by Crichton and colleagues found the strongest evidence for the effect against nausea in pregnant women, with a large effect and a high GRADE rating. But depending on the occasion, the picture looks different.
In pregnancy
A team around Viljoen pooled 12 randomised trials with 1278 pregnant women who received ginger versus placebo or a comparator.
Nausea improved significantly more with ginger than with placebo (MD 1.20; 95% CI 0.56 to 1.84). The number of vomiting episodes did not fall significantly, it remained a trend (MD 0.72; 95% CI -0.03 to 1.46; p = 0.06). For the risk of miscarriage there was no significant difference, with a very wide confidence interval (RR 3.14; 95% CI 0.65 to 15.11).
What this means for you: ginger may ease the feeling of nausea; for vomiting this is not established. And for miscarriage risk, not significant does not mean safely ruled out. The authors themselves point to the low quality of the evidence.
Viljoen E, Visser J, Koen N, Musekiwa A. Nutr J. 2014;13:20. PMID: 24642205 · DOI: 10.1186/1475-2891-13-20 [Meta-analysis, 12 RCTs, n=1278]Cochrane is more cautious. The review by Matthews and colleagues of 41 trials with 5449 women calls the evidence for ginger limited and not consistent, but stresses: for no remedy against early pregnancy nausea is there high-quality evidence, and that does not mean the remedies are ineffective.
On safety there is a large observational study. In the Norwegian Mother and Child Cohort, 1,020 of 68,522 women reported having used ginger during pregnancy. No increased risk of malformations, stillbirth, preterm birth, low birth weight or a low Apgar score was found (Heitmann 2013). The Embryotox counselling centre at Charité writes that ginger can be taken at usual doses in all phases of pregnancy.
Why other bodies are more cautious
EU monograph: it refers to data on 300 to 1000 pregnancy outcomes without any indication of malformations, but considers the animal data on reproduction insufficient. In experiments on pregnant rodents, ginger powder or aqueous extracts led to more embryo resorptions. Its conclusion: as a precaution, use during pregnancy is best avoided.
Danish risk assessment 2018: a single ginger shot corresponds to the juice of 1.7 to 23 g of fresh root. The safety margin to the harmful dose from rat experiments was therefore between 74 and 6, where at least 100 is customary. A risk to the unborn child could not be ruled out with large amounts of ginger in shots.
Guidelines: the 2024 British guideline advises health professionals not to refer women with severe nausea or hyperemesis to ginger, because this can delay effective treatment. The US professional society ACOG calls ginger a non-drug option that can be considered for nausea, at Level B. [Guideline]
Both are true at the same time. For mild nausea, ginger is a comparatively well studied option. Concentrated shots and high-dose preparations are something else. Severe nausea belongs in medical treatment, and there are tested medications for it in pregnancy. Before any ginger preparation and before using ginger specifically against nausea, talk to your gynaecologist, ideally also to your midwife, and do not replace prescribed anti-nausea medication with ginger.
After surgery
A meta-analysis by Lu and colleagues with 14 randomised trials and 1,506 patients found lower nausea scores with ginger 2, 6 and 12 hours after surgery. Outside the recovery room, vomiting and the need for anti-nausea medication did not differ.
A network meta-analysis by Zhao and colleagues with 2199 participants painted a different picture. Ginger oil had the highest probability of reducing vomiting (RR 0.39; 95% CI 0.16 to 0.96). For the occurrence of nausea, no ginger variant showed statistical superiority over placebo, although nausea intensity and the need for anti-nausea medication were lower with ginger powder and ginger oil. Honest label: mixed.
During chemotherapy
A meta-analysis by Crichton and colleagues found a signal on nausea and vomiting only for acute vomiting, namely in a subgroup with no more than 1 g of ginger per day for more than three days (study data): in three trials with 301 participants it was less frequent with ginger (OR 0.4; 95% CI 0.17 to 0.81). For nausea, overall vomiting, delayed vomiting and other outcomes related to nausea and vomiting, no significant association was found.
The German S3 guideline on complementary medicine in oncology, version 2.0 from 2024, evaluated 2 systematic reviews with 8 RCTs and 12 further RCTs. Recommendation 7.68 reads: ginger can be used in addition to guideline-based antiemetic therapy in the treatment of chemotherapy-induced nausea and vomiting. That is recommendation grade 0, the weakest level. According to statement 7.67, there are insufficient data on mortality, disease-associated morbidity and quality of life.
What this means for you: in oncology, ginger is a possible addition, never a replacement for the anti-nausea medication your treatment team prescribes.
Leitlinienprogramm Onkologie (DKG, DKH, AWMF). S3-Leitlinie Komplementärmedizin in der Behandlung von onkologischen PatientInnen. Version 2.0, May 2024. AWMF register number 032-055OL [Guideline]A review by Burg and colleagues of 24 studies with 2409 people with cancer describes inconsistent results, and two studies even found disadvantages. That is why you should raise ginger openly with your oncology team.
When travelling
And the only well-established EU use? The studies are old and small. In Lien and colleagues, ginger reduced artificially induced motion sickness, gastric rhythm disturbances and the hormone vasopressin in 13 volunteers. In Stewart and colleagues, ginger did not protect 28 volunteers in a rotating chair, whereas scopolamine did. The monograph gives 1 to 2 g for adults one hour before the start of travel Monograph figure, not a recommendation.
In the studies, ginger tends to show an effect on the feeling of nausea rather than on vomiting itself.
If you can no longer drink, you need more than a home remedy.
And now you know why the same root is named as an option in pregnancy and at the same time comes with a note of caution.
Pain in numbers: period pain, joints and migraine
The hot water bottle is already on your belly. Can a root do more?
Period pain
Here there are surprisingly many studies. A meta-analysis by Moshfeghinia and colleagues found lower pain intensity compared with placebo (SMD -1.13; 95% CI -1.59 to -0.68) and a shorter pain duration (SMD -0.29). Compared with non-steroidal anti-inflammatory drugs, NSAIDs for short, and with exercise, there was no difference. Heterogeneity was high (I² 81.05%), and safety data were rare. And no difference from NSAIDs is not proof of equivalence.
A team around Pattanittum examined 27 randomised trials with 3101 women on dietary supplements for period pain for Cochrane. 22 of them came from Iran.
For ginger they found very limited evidence of benefit, with a difference of -1.55 points in pain across three trials with 266 women. They rated the overall evidence as low or very low, and evidence on safety was lacking.
What this means for you: the signal is there, the quality is weak. Severe period pain that takes you out of everyday life needs medical assessment, because endometriosis may be behind it.
Pattanittum P, Kunyanone N, Brown J, et al. Cochrane Database Syst Rev. 2016;3(3):CD002124. PMID: 27000311 · DOI: 10.1002/14651858.CD002124.pub2 [Systematic Review, Cochrane, 27 RCTs]For PMS there is one small double-blind study with 70 women: symptoms differed significantly in favour of ginger, and the team itself phrases its conclusion with a maybe. More in Understanding PMS. No study I found showed that ginger can bring on a period.
Osteoarthritis
A team around Bartels pooled five placebo-controlled trials with 593 people with osteoarthritis.
Pain decreased statistically significantly with ginger, to a small extent (SMD -0.30; 95% CI -0.50 to -0.09). At the same time, people taking ginger dropped out more than twice as often as those on placebo (RR 2.33; 95% CI 1.04 to 5.22). The authors speak of modest efficacy and reasonable safety, with evidence of moderate quality.
What this means for you: a small effect, and more people who stopped taking it.
Bartels EM, Folmer VN, Bliddal H, et al. Osteoarthritis Cartilage. 2015;23(1):13-21. PMID: 25300574 · DOI: 10.1016/j.joca.2014.09.024 [Meta-analysis, 5 RCTs, n=593]Assessments differ. Araya-Quintanilla and colleagues consider the evidence for ingested ginger in knee osteoarthritis insufficient. The umbrella review by Crichton rates the effect as small, with high GRADE certainty. The EU monograph lists mild joint pain only as a traditional use.
Botanically, turmeric also belongs to the ginger family, more on that in Turmeric and inflammation. Frankincense is associated with a different inflammatory pathway, more on that in Frankincense for joints and gut.
Migraine
With the head, the data become thinnest. The most recent assessment by Atkins and colleagues covers eight randomised trials with 594 people. Their conclusion: it is currently too uncertain whether ginger is effective as acute treatment or for prevention.
As an add-on to a painkiller, in one study with 60 people they see possibly little to no difference after two hours. As an add-on to preventive medication, two studies with 183 people showed a possibly meaningful reduction in pain after three months. Both with low certainty of evidence. They rate the comparison with a triptan without a placebo group as very uncertain. In a study by Martins and colleagues with 107 people, ginger alone over three months brought no greater preventive benefit than placebo.
None of this is a reason to leave out a triptan, a painkiller or prescribed migraine prophylaxis. Sudden, worst-ever headache or new neurological deficits need immediate medical assessment.
| Use | Best source | Effect | Certainty of evidence |
|---|---|---|---|
| Period pain | Moshfeghinia 2024, Cochrane 2016 | SMD -1.13 versus placebo, no difference from NSAIDs | low to very low according to Cochrane |
| Osteoarthritis | Bartels 2015, Crichton 2022 | SMD -0.30, more dropouts | moderate to high, dissenting view Araya-Quintanilla 2020 |
| Migraine | Atkins 2026 | too uncertain for a conclusion | low to very low |
For osteoarthritis, small but measurable is more honest than anti-inflammatory.
And now you know why ginger has the most studies for period pain, the calmest finding for the knee and the greatest uncertainty for the head.
Stomach and digestion: emptying faster, but not always feeling better
After a meal, everything sits in your belly like a stone, and someone recommends ginger tea.
Picture the stomach as a kneading machine with an outlet valve. Its lower part, the antrum, kneads the food pulp and pushes it on portion by portion. Exactly this movement was measured with ginger.
A team around Wu gave 24 healthy people 1200 mg of ginger or placebo on two occasions, one hour before 500 ml of soup, and tracked gastric emptying by ultrasound.
After ginger, the stomach was half empty after 13.1 minutes, after placebo after 26.7 minutes. Contractions in the antrum were more frequent. There was no difference in gastrointestinal symptoms.
What this means for you: ginger can speed up gastric emptying. Whether that makes you feel better, this study did not show.
Wu KL, Rayner CK, Chuah SK, et al. Eur J Gastroenterol Hepatol. 2008;20(5):436-40. PMID: 18403946 · DOI: 10.1097/MEG.0b013e3282f4b224 [RCT, crossover, n=24]This fits the EU monograph, which lists mild cramp-like gastrointestinal complaints with bloating and temporary loss of appetite as traditional uses, and Commission E with dyspeptic complaints. Relief of these complaints is not clinically established by this.
The same monograph also lists the common side effects: stomach discomfort, belching, indigestion, heartburn and nausea. That is not a contradiction, but the same property seen from two sides.
Through the lifestyle lens: a spice does not make up for hasty eating, constant stress or lack of sleep.
If fullness, early satiety or upper abdominal pain have been with you for weeks, it is worth looking for the cause before the next home remedy. What may lie behind functional dyspepsia and when delayed gastric emptying comes into question, I describe separately. If you are prone to heartburn, notice whether ginger makes it worse, more in Understanding heartburn. Unintended weight loss, difficulty swallowing, vomiting blood or black stools need immediate medical assessment.
And the microbiome? In a placebo-controlled study with healthy young adults, ginger powder changed individual aspects of bacterial composition. What that means is covered in Medicinal plants and the gut.
Emptying faster does not automatically mean better. The same pungency that can get the stomach moving can also irritate it.
And now you know why ginger can push digestion along for some people and cause heartburn in others.
Blood sugar, blood lipids, blood pressure, weight and liver: reading small numbers correctly
A short video says: ginger lowers blood sugar, blood pressure and belly fat. The numbers behind this exist. They just tell a quieter story.
Significant is not the same as meaningful
Statistically significant means: the difference is probably not due to chance. Clinically meaningful means: the difference is large enough to change something for your health. With ginger, the first is often true, the second is not.
Blood sugar. In type 2 diabetes, a meta-analysis by Chen and colleagues of 13 papers found lower values for fasting glucose (MD -16.27 mg/dl) and HbA1c (MD -0.41%), with very high heterogeneity. The authors themselves rate the magnitude as of limited clinical relevance. A second meta-analysis by Schumacher and colleagues of five randomised trials found no significant effect on fasting glucose and HbA1c. Honestly summarised: contradictory, small at most.
Blood lipids. A meta-analysis by Salih and colleagues found lower values for total cholesterol (SMD -0.44) and triglycerides (SMD -0.61). LDL and HDL did not change significantly. That is no substitute for prescribed lipid-lowering therapy.
A team around Karimi analysed twelve randomised trials on ginger and blood pressure in 2026 and rated the evidence using GRADE.
Systolic blood pressure was 5.03 mmHg lower (95% CI -8.49 to -1.57), diastolic 2.03 mmHg lower (95% CI -3.90 to -0.15). Certainty of evidence was low, the studies short and heterogeneous, and the data were not sufficient for a clinical or dose recommendation.
What this means for you: a slight effect in short studies, not a blood pressure medication. For the widespread worry that ginger raises blood pressure, no study turned up in the research.
Karimi M, Asbaghi O, Rafiei H, et al. J Hum Nutr Diet. 2026;39(4):e70329. PMID: 42566667 · DOI: 10.1111/jhn.70329 [Meta-analysis, 12 RCTs]Weight. A meta-analysis by Rafieipour and colleagues of 27 randomised trials with 1309 participants found a pooled weight difference of -1.52 kg (95% CI -2.37 to -0.66). Certainty of evidence was low for body weight and very low for waist circumference and BMI. That is a study figure, not a goal. Weight depends on many building blocks, see Understanding weight holistically.
Liver. In fatty liver, liver enzymes fell with ginger in a study by Ghoreishi and colleagues with 76 people with type 2 diabetes, but also with placebo. The Fibroscan measurements of liver fat did not change significantly. According to the US database LiverTox, no liver damage was reported in more than 100 clinical trials with ginger, although few of these trials specifically monitored liver values. A single case report from Japan describes acute liver injury with jaundice under a product said to contain ginger, whose composition was not analysed. These data offer nothing to support a detox promise. What matters for the liver is covered in Liver detox: what counts and what is marketing.
Ginger can be part of a diet; it is not a counterweight to lack of exercise or lack of sleep. If you take blood pressure medication, diabetes medication or lipid-lowering drugs, do not change them because of these numbers, and discuss larger amounts of ginger as a preparation beforehand.
A spice with an HbA1c difference of -0.41% in studies is interesting. It is not a reason to leave out a medication.
And now you know why the phrase proven to lower in such videos promises more than the meta-analyses deliver.
Colds, ginger shots, mental health and hormones: where tradition, hype and studies part ways
The tea is steaming, your nose is running. It feels as if it is doing something.
Colds and the immune system
Since the 2025 revision, the EU monograph lists the relief of cold symptoms as a traditional use. So: long experience, no study evidence. A targeted PubMed search for clinical studies on ginger for colds, carried out during the research for this article, returned not a single hit. Tradition
A team around Chang applied hot water extracts of fresh and dried ginger to human respiratory tract cell lines infected with the respiratory virus RSV.
Fresh ginger inhibited plaque formation by the virus in a dose-dependent manner. At 300 μg/ml, the number of plaques in the two cell lines fell to 19.7% and 27.0% of the control, respectively. Dried ginger showed no dose-dependent inhibition.
What this means for you: an interesting lab finding, not evidence against colds in humans. Between a cell culture dish and your nose lie digestion, absorption and metabolism.
Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. J Ethnopharmacol. 2013;145(1):146-51. PMID: 23123794 · DOI: 10.1016/j.jep.2012.10.043 [In vitro, cell lines]What remains is plausible and human: warmth, fluids, steam and the ritual of taking care of yourself. That is a conjecture, not a measured result. How the notion of immune boosting can be put into context, using cold exposure as an example, is covered in Cold, the immune system and hormesis.
Compresses and footbaths: the anthroposophic lens
In anthroposophic and integrative nursing, ginger compresses and ginger footbaths have a firm place, for example for respiratory infections or for falling asleep. That is clinical tradition, and remarkably, researchers from precisely this setting have critically tested their own applications.
In a crossover study by Vagedes and colleagues, 18 healthy young adults received chest compresses with mustard, with ginger or with warm water only on the upper back. Mustard and ginger both produced a sensation of warmth, but the skin became measurably warmer only with mustard. An effect on infections was not studied.
In a randomised study by Kuderer and colleagues, 28 people with long-standing sleep problems took an evening footbath for two weeks, in warm water alone or with 80 g of ginger powder. Both groups slept better over time. The ginger brought no additional effect on sleep, only more sensation of warmth in the feet, which is why the authors tend to recommend warm water alone for this group.
Ginger shots
60 millilitres, sharp as a wake-up call, and the word immune system on the label. Two German consumer advice centres have looked at what is inside.
In 2021, the consumer advice centre of Schleswig-Holstein examined 48 ginger shots in food shops in Kiel. The consumer advice centre of Rhineland-Palatinate took another look at the range in 2025.
In 2021, the ginger content averaged 14.5 percent. In many cases there was hardly more in the bottle than apple juice, orange juice and water, with about 9 g of sugar per 100 ml, roughly as much as in cola. In 2025, according to the updated version of 26 August 2026, the shots consisted of two thirds apple or orange juice, with an average of 18 percent ginger, and even organic own brands without added sugar were above 7 g of sugar per 100 ml because of their juice content.
What this means for you: a shop-bought ginger shot is mainly juice with ginger, not ginger with a little juice.
Verbraucherzentrale Schleswig-Holstein, press release of 02.12.2021; Verbraucherzentrale Rheinland-Pfalz, press release of 11.02.2025 [Market check, consumer advice centre]For the teeth, the issue is less the ginger than the combination of acid, sugar and daily repetition. According to a review by Saads Carvalho and Lussi, frequent consumption of fruit juices is significantly associated with more erosive tooth wear, and swishing drinks around in the mouth tends to promote erosion. No study on ginger shots themselves was found, including none on yellow teeth.
For a sensitive stomach, the consumer advice centre suggests drinking only a little at a time and adjusting the pungency. In pregnancy, the Danish risk assessment views concentrated shots critically, and on anticoagulants a daily shot belongs in a conversation with your doctor.
And the shot for weight loss? A sugary juice is not a weight loss tool, and the study figures on weight cannot be transferred to shop-bought shots. The parallel to juice cleanses is obvious, more on that in Juice cleanses under critical review. What role fructose plays in metabolism is covered in Sugar, fructose and the liver. If you like shots, read the ingredients list and the sugar content.
Mental health, sleep and hormones
On mental health and sleep, the story is quickly told. In a placebo-controlled study by Crichton and colleagues with 51 healthy adults aged 18 to 30, 14 days of ginger powder changed neither mood nor quality of life. No robust study on ginger alone for depression or anxiety was found, and none on ingested ginger and sleep. If you sleep badly after ginger in the evening, pungency or heartburn could play a role, as a conjecture without a study. For persistent sleep problems or low mood, a medical assessment is the better path than a spice. If thoughts of not wanting to live anymore come up, get help immediately: Telefonseelsorge 0800 111 0 111 or 0800 111 0 222, around the clock and free of charge, and in acute danger the emergency number 112. These are German numbers; outside Germany, please use your local crisis line and emergency number. Plant-based options for sleep: Valerian and passionflower.
With hormones, precision pays off. A review by Banihani summarises studies in which ginger increased testosterone production in males, especially under oxidative stress, mostly in animal experiments. According to the author, this has not yet been confirmed in humans. The EU monograph, too, describes higher testosterone levels only in male rats. Animal What over-the-counter preparations can do for testosterone is covered in Testosterone boosters and the evidence.
A warm ginger tea can feel good. That it shortens a cold, no study has shown so far.
And the words immune system on the label of a shot are not a study result.
And now you know why the most famous use of ginger is the least researched, and why a shop-bought shot is mostly juice.
Plant-based does not mean harmless: safety, interactions and who should be careful
It's only a spice, isn't it?
In the kitchen, that is exactly what ginger is for most people. The US database LiverTox lists it as GRAS, short for generally recognized as safe. But as soon as the spice becomes a capsule, an extract or a daily shot, the question changes.
Plant-based does not mean harmless. It means: the substances come from a plant, and they deserve the same care as any other preparation.
Common side effects
The EU monograph lists stomach discomfort, belching, indigestion, heartburn and nausea as common, meaning in at least 1 in 100 and fewer than 1 in 10 people treated. Hypersensitivity reactions are possible, their frequency is unknown. In the pregnancy trials, heartburn did not occur significantly more often with ginger than with placebo. In the osteoarthritis trials, by contrast, people taking ginger dropped out more than twice as often.
Anticoagulants
The cautious side
A German summary of product characteristics, cited in the EU assessment report, warns of an increased effect of anticoagulants. In an observational study by Shalansky and colleagues with 171 people on warfarin, ginger was associated with more frequent self-reported bleeding (OR 3.20; 95% CI 2.42 to 4.24).
The more relaxed side
The HMPC considers case reports of interactions with anticoagulants few and unconvincing and did not include a warning. It stresses, however, that results from healthy volunteers cannot simply be transferred to people on long-term therapy. In twelve healthy men, ginger did not change the INR after a single dose of warfarin. In the review by Marx and colleagues, four of eight clinical studies on platelet aggregation found inhibition, four found no effect.
With anticoagulants, open means caution, not all clear. The study by Jiang and colleagues does not represent people on long-term therapy, other anticoagulants or with pre-existing conditions. The study by Shalansky and colleagues relies on self-report and cannot establish causation, and excessive INR values there were only associated with taking warfarin for less than three months. What follows is a direction, not a ban: if you take anticoagulants or antiplatelet drugs, discuss capsules, extracts and daily shots with the prescribing practice. Whether kitchen amounts already make a difference has not been studied. Never change the anticoagulant itself on your own.
Before surgery
A German summary of product characteristics advises stopping a ginger medicine because of an increased bleeding tendency when surgery is planned. A review by Hatfield and colleagues considers the data on bleeding risk contradictory and names discontinuing non-essential dietary supplements two weeks before surgery as best practice. What this means for you: mention ginger preparations and daily shots in the consultation before any planned operation, and plan the approach together with the surgical and anaesthesia team.
Gallstones
According to Commission E and a German summary of product characteristics, ginger medicines should only be used for gallstone disease after consulting a doctor. No clinical study on this was found. The warning follows the precautionary principle and, according to secondary sources, the bile-stimulating property that Commission E attributes to ginger. Whether this should be assessed differently without a gallbladder, data are lacking. That belongs in a conversation with your doctor.
Diabetes and blood pressure medication
No study was found on interactions with glucose-lowering medication or blood pressure medication. The small effects on blood sugar and blood pressure in meta-analyses are nonetheless a reason to discuss larger amounts as a preparation beforehand, especially when the medication is finely adjusted. Hypoglycaemia caused by ginger is not established. And this is expressly not a guide to changing anything about your medication.
Pregnancy, breastfeeding and children
On pregnancy, both sides are set out in the section on nausea. For breastfeeding, the EU monograph does not recommend ginger medicines, whereas Embryotox writes that ginger appears to be acceptable during breastfeeding. For children and adolescents under 18, the monograph generally does not recommend ginger medicines. Only for the traditional use in motion sickness is the limit 6 years. In pregnancy and breastfeeding and for children, the rule is therefore: discuss preparations with a doctor beforehand, and in pregnancy and breastfeeding ideally also with your midwife.
And how much?
No universally valid daily amount can be derived from the studies. The umbrella review by Crichton and colleagues reports amounts of 0.5 to 3 g per day in capsule form for up to three months consistently across the included studies, with great heterogeneity between studies and poorly described preparations Study figure, not a recommendation. Ginger as a spice in food is different from an extract, a capsule or a daily shot. If you take medication, are pregnant or have pre-existing conditions, the amount belongs in a conversation with your doctor.
Plant-based describes the origin, not harmlessness. The spice in your food and the daily capsule are two different questions.
Three directions instead of a recipe
- Enjoy ginger as a spice and as a tea, without burdening it with therapeutic expectations. Warmth, flavour and ritual are allowed to simply feel good.
- For mild nausea, period pain or joint pain, ginger can be one building block. The question of the cause still matters, especially if symptoms are severe or persist.
- Raise preparations and shots openly if you are pregnant or breastfeeding, take anticoagulants, diabetes or blood pressure medication, have gallstones or have an operation ahead of you.
Whether dietary supplements make sense at all, I describe in principle in Dietary supplements and homeostasis. And because the term comes up often: ginger is deliberately not called an adaptogen here. What this term means and what it does not, I explain in Adaptogens explained.
In the end, this is not about a root. It is about a kind of freedom: enjoying home remedies without expecting more of them than they can deliver, and without putting off important things because of them.
If you'd like to do more than read and get started right away: below this article you will find the option to book an appointment.
And now you know why, with ginger, I don't ask whether it is good or bad, but in what form, in what amount and for whom.
Frequently asked questions about ginger
What does ginger do in the body?
Ginger has been studied most for nausea, especially in pregnancy. In a small study with healthy people, the stomach emptied faster after ginger. In the lab, its pungent compounds inhibited serotonin receptors involved in nausea. Many of the often cited anti-inflammatory effects, by contrast, come from cell and animal experiments.
Is fresh or dried ginger better?
Chemically, the two are different. Fresh ginger contains mainly gingerols, and drying and heating turn them into shogaols. Which form does more in humans has not been compared directly. Only in one cell culture study did fresh ginger, but not dried ginger, inhibit a respiratory virus, and that cannot be transferred to humans.
Can ginger help with nausea?
In meta-analyses, ginger may ease the feeling of nausea in pregnancy, while the number of vomiting episodes did not fall significantly. After surgery and during chemotherapy, the results are mixed. According to the German S3 guideline, ginger can be used during chemotherapy in addition to guideline-based antiemetic therapy, not in its place. The EU monograph lists only the prevention of motion sickness as a well-established medical use.
Can I take ginger during pregnancy?
Assessments differ. According to Embryotox, ginger can be taken at usual doses in all phases of pregnancy, and a Norwegian cohort including 1,020 pregnant women who used ginger found no increased risk of malformations. The EU monograph advises restraint with ginger medicines as a precaution, and a Danish risk assessment views concentrated shots critically. Before taking preparations or using ginger specifically against nausea, talk to your gynaecologist, and ideally also to your midwife. If you can barely drink or are vomiting heavily, you need medical help.
What does ginger tea do for a cold?
Since 2025, the EU monograph lists the relief of cold symptoms as a traditional use, meaning it is based on long experience rather than clinical studies. No clinical study on ginger for colds was found during the research for this article, only cell culture data. Warmth and fluids can still feel good.
Can ginger support weight loss?
A meta-analysis of 27 randomised trials with 1309 participants found a pooled weight difference of -1.52 kg, with low certainty of evidence. That is a study figure, not a goal. A shop-bought ginger shot is different from a study preparation: in one market check, shots contained on average about 9 g of sugar per 100 ml.
What does ginger do to blood pressure, cholesterol and blood sugar?
In a meta-analysis of twelve trials, systolic blood pressure was 5.03 mmHg lower, with low certainty of evidence. Total cholesterol and triglycerides fell in another analysis, LDL did not change significantly. In type 2 diabetes, the HbA1c effect was small and, according to the authors, of limited clinical relevance, and a second analysis found no significant effect. Please do not change prescribed medication on your own.
What do studies show about ginger in women, men and hormones?
For period pain there is a signal, but Cochrane rates the evidence as low or very low. For PMS there is one small study with 70 women. Indications of higher testosterone come mainly from animal experiments and have not been confirmed in humans. Severe period pain should be assessed by a doctor.
What do studies show about ginger, mental health and sleep?
In 51 healthy young adults, ginger powder taken over 14 days changed neither mood nor quality of life. No study on ingested ginger and sleep was found. An evening footbath with ginger did not improve sleep more than warm water alone. For persistent sleep problems or low mood, a medical assessment is the better path.
Is a ginger shot healthy?
Market checks by two German consumer advice centres found on average 14.5 and 18 percent ginger respectively, plus a lot of juice, with about 9 g of sugar per 100 ml, and more than 7 g for organic own brands without added sugar. Acid and sugar can strain the teeth with frequent consumption, and the pungency can irritate a sensitive stomach. In pregnancy, a Danish risk assessment views concentrated shots critically.
How much ginger per day is okay?
No universally valid daily amount can be derived from the studies. One review reports amounts of 0.5 to 3 g per day in capsule form for up to three months consistently across studies, which is a study figure, not a recommendation. Ginger as a spice is different from extracts, capsules or daily shots. If you take medication, are pregnant or have pre-existing conditions, the amount belongs in a conversation with your doctor.
Can I eat ginger while taking blood thinners?
The evidence is contradictory. In twelve healthy men, ginger did not change the INR after a single dose of warfarin, while in an observational study of people on warfarin, those using ginger reported bleeding more often. A German summary of product characteristics for ginger medicines warns of an increased effect of anticoagulants. Whether kitchen amounts already make a difference has not been studied. Discuss preparations, capsules or daily shots with the prescribing practice, and never change your anticoagulant yourself.
Is ginger bad for the liver or gallbladder?
According to the US database LiverTox, no liver damage was reported in more than 100 clinical trials with ginger, although few of these trials specifically monitored liver values. For gallstones, ginger medicines should only be used after consulting a doctor, according to Commission E and a German summary of product characteristics, and clinical studies on this are lacking. Severe upper abdominal pain with fever or yellowing of the skin needs immediate medical assessment.
What side effects does ginger have, and can it cause heartburn?
According to the EU monograph, stomach discomfort, belching, indigestion, heartburn and nausea are common, meaning they occur in at least 1 in 100 and fewer than 1 in 10 people treated. In osteoarthritis trials, people taking ginger dropped out more than twice as often as those on placebo. If you are prone to heartburn, notice whether ginger makes it worse, and have persistent symptoms checked by a doctor.
Where ginger connects to other topics
Ginger rarely stands alone. It touches the stomach, the menstrual cycle, the joints, metabolism and the question of when a preparation makes sense. Here is where to go next.
Curcumin and the question of absorption
Why little free active compound from turmeric reaches the blood and what capsule forms are meant to change about that.
If inflammation is your topicTurmeric and inflammation
The related plant from the ginger family, with the state of the evidence and the limits of the hype.
If joints are the topicFrankincense for joints and gut
Another medicinal plant with its own inflammatory pathway and its own body of evidence.
If the gut interests youMedicinal plants and the microbiome
How herbs come into contact with gut bacteria and what studies show about it.
If your stomach keeps feeling heavyUnderstanding functional dyspepsia
What may lie behind fullness and upper abdominal pain without a visible finding.
If period pain takes you out of everyday lifeEndometriosis from an integrative view
Why severe period pain deserves assessment and what an integrative perspective looks like.
If shots and juice cleanses tempt youJuice cleanses and detox teas under critical review
What lies behind the promise of liquid cleansing regimens and what studies have to say about it.
If you are thinking about supplementsWhen dietary supplements make sense
A perspective before capsules become a daily habit.
If pungency gives you heartburnUnderstanding heartburn
Where heartburn comes from and how the symptoms can be put into context.
If the term adaptogen comes upAdaptogens explained
What the term means and what it does not promise.
If the liver is the focusMilk thistle and the liver
Another medicinal plant caught between detox promises and the evidence.
Scientific sources
- Committee on Herbal Medicinal Products (HMPC), European Medicines Agency. European Union herbal monograph on Zingiber officinale Roscoe, rhizoma. Final, Revision 1. EMA/HMPC/885789/2022. Adopted on 07.05.2025. ema.europa.eu [Regulatory document, EU monograph]
- Committee on Herbal Medicinal Products (HMPC), European Medicines Agency. Assessment report on Zingiber officinale Roscoe, rhizoma. Final, Revision 1. EMA/HMPC/765220/2022. 07.05.2025. ema.europa.eu [Regulatory document, assessment report]
- Commission E at the Federal Health Office (Kommission E beim Bundesgesundheitsamt). Monographie Zingiberis rhizoma (Ingwerwurzelstock). (Monograph on ginger rhizome.) Bundesanzeiger No. 85 of 05.05.1988; corrections BAnz. No. 50 of 13.03.1990 and No. 164 of 01.09.1990. Content via two consistent secondary sources. [Regulatory document, Commission E monograph]
- German Guideline Program in Oncology (Leitlinienprogramm Onkologie: Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF). S3-Leitlinie Komplementärmedizin in der Behandlung von onkologischen PatientInnen. (S3 guideline on complementary medicine in the treatment of cancer patients.) Short version 2.0, May 2024. AWMF register number 032-055OL. register.awmf.org [Guideline]
- Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists. The Management of Nausea and Vomiting in Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No. 69). BJOG. 2024;131(7):e1-e30. PMID: 38311315 · DOI: 10.1111/1471-0528.17739 [Guideline]
- Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PMID: 29266076 · DOI: 10.1097/AOG.0000000000002456 [Guideline]
- Pharmacovigilance and Advisory Centre for Embryonal Toxicology (Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie), Charité-Universitätsmedizin Berlin. Embryotox: Ingwer. (Ginger.) Accessed 16.09.2026. embryotox.de [Regulatory document, advisory centre]
- DTU Fødevareinstituttet (Bager F). Notat til Fødevarestyrelsen: Sikkerheden for gravide ved indtag af ingefærshots fremstillet af roden fra ægte ingefær (Zingiber officinale Roscoe). Mulig interaktion mellem ingefær og warfarin. (Memo to the Danish Veterinary and Food Administration on the safety of ginger shots for pregnant women and a possible interaction between ginger and warfarin.) 21.12.2018. DTU DOC nr. 18/15564. food.dtu.dk [Regulatory document, risk assessment]
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Ginger. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases. Last updated 10.02.2024. NBK600585. PMID: 38381909 [Regulatory document, database]
- Verbraucherzentrale Schleswig-Holstein (consumer advice centre). Ingwershots: Überteuert, überzuckert und überschätzt. (Ginger shots: overpriced, oversugared and overrated.) Press release of 02.12.2021. verbraucherzentrale.sh [Market check, consumer advice centre]
- Verbraucherzentrale Rheinland-Pfalz (consumer advice centre). Ingwershots: Wenig Ingwer, viel Saft und Zucker. (Ginger shots: little ginger, lots of juice and sugar.) Press release of 11.02.2025, updated version of 26.08.2026. verbraucherzentrale-rlp.de [Market check, consumer advice centre]
- Crichton M, Davidson AR, Innerarity C, Marx W, Lohning A, Isenring E, Marshall S. Orally consumed ginger and human health: an umbrella review. Am J Clin Nutr. 2022;115(6):1511-1527. PMID: 35147170 · DOI: 10.1093/ajcn/nqac035 [Umbrella Review, 24 systematic reviews]
- Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry. 2015;117:554-568. PMID: 26228533 · DOI: 10.1016/j.phytochem.2015.07.012 [Review, chemistry]
- Pázmándi K, Szöllősi AG, Fekete T. The "root" causes behind the anti-inflammatory actions of ginger compounds in immune cells. Front Immunol. 2024;15:1400956. PMID: 39007134 · DOI: 10.3389/fimmu.2024.1400956 [Review, cell and animal data]
- Zick SM, Djuric Z, Ruffin MT, Litzinger AJ, Normolle DP, Alrawi S, Feng MR, Brenner DE. Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 2008;17(8):1930-6. PMID: 18708382 · DOI: 10.1158/1055-9965.EPI-07-2934 [Human study, pharmacokinetics, n=27]
- Walstab J, Krüger D, Stark T, Hofmann T, Demir IE, Ceyhan GO, Feistel B, Schemann M, Niesler B. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil. 2013;25(5):439-47, e302. PMID: 23490018 · DOI: 10.1111/nmo.12107 [In vitro, human receptors and tissue]
- Viljoen E, Visser J, Koen N, Musekiwa A. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J. 2014;13:20. PMID: 24642205 · DOI: 10.1186/1475-2891-13-20 [Meta-analysis, 12 RCTs, n=1278]
- Matthews A, Haas DM, O'Mathúna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2015;2015(9):CD007575. PMID: 26348534 · DOI: 10.1002/14651858.CD007575.pub4 [Systematic Review, Cochrane, 41 trials, n=5449]
- Heitmann K, Nordeng H, Holst L. Safety of ginger use in pregnancy: results from a large population-based cohort study. Eur J Clin Pharmacol. 2013;69(2):269-77. PMID: 22706624 · DOI: 10.1007/s00228-012-1331-5 [Cohort, n=68,522]
- Lu C, Chen X, Yan X, He J, Nie Z. The preventive and relieving effects of ginger on postoperative nausea and vomiting: A systematic review and meta-analysis of randomized controlled trials. Int J Nurs Stud. 2022;125:104094. PMID: 34700257 · DOI: 10.1016/j.ijnurstu.2021.104094 [Meta-analysis, 14 RCTs, n=1,506]
- Zhao C, Chen W, Wang D, Cong X, Zhu M, Zhu C, Xu J, Cai J. Ginger (Zingiber officinale Roscoe) preparations for prophylaxis of postoperative nausea and vomiting: A Bayesian network meta-analysis. J Ethnopharmacol. 2023;317:116791. PMID: 37379959 · DOI: 10.1016/j.jep.2023.116791 [Meta-analysis, network, n=2199]
- Crichton M, Marshall S, Marx W, McCarthy AL, Isenring E. Efficacy of Ginger (Zingiber officinale) in Ameliorating Chemotherapy-Induced Nausea and Vomiting and Chemotherapy-Related Outcomes: A Systematic Review Update and Meta-Analysis. J Acad Nutr Diet. 2019;119(12):2055-2068. PMID: 31519467 · DOI: 10.1016/j.jand.2019.06.009 [Meta-analysis, 18 articles]
- Burg SC, Dörfler J, Büntzel J, Büntzel J, Huebner J. Ginger in supportive therapy against side effects of oncological treatment: a systematic review. BMC Complement Med Ther. 2026;26(1):249. PMID: 42613614 · DOI: 10.1186/s12906-026-05530-z [Systematic Review, 24 studies, n=2409]
- Lien HC, Sun WM, Chen YH, Kim H, Hasler W, Owyang C. Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol Gastrointest Liver Physiol. 2003;284(3):G481-9. PMID: 12576305 · DOI: 10.1152/ajpgi.00164.2002 [RCT, crossover, n=13]
- Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology. 1991;42(2):111-20. PMID: 2062873 · DOI: 10.1159/000138781 [Controlled trial, n=28]
- Moshfeghinia R, Salmanpour N, Ghoshouni H, Gharedaghi H, Zare R, Cramer H, Heydarirad G, Pasalar M. Ginger for Pain Management in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis. J Integr Complement Med. 2024;30(11):1016-1030. PMID: 38770631 · DOI: 10.1089/jicm.2023.0799 [Meta-analysis, 12 studies pooled quantitatively]
- Pattanittum P, Kunyanone N, Brown J, Sangkomkamhang US, Barnes J, Seyfoddin V, Marjoribanks J. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016;3(3):CD002124. PMID: 27000311 · DOI: 10.1002/14651858.CD002124.pub2 [Systematic Review, Cochrane, 27 RCTs, n=3101]
- Khayat S, Kheirkhah M, Behboodi Moghadam Z, Fanaei H, Kasaeian A, Javadimehr M. Effect of treatment with ginger on the severity of premenstrual syndrome symptoms. ISRN Obstet Gynecol. 2014;2014:792708. PMID: 24944825 · DOI: 10.1155/2014/792708 [RCT, n=70]
- Bartels EM, Folmer VN, Bliddal H, Altman RD, Juhl C, Tarp S, Zhang W, Christensen R. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2015;23(1):13-21. PMID: 25300574 · DOI: 10.1016/j.joca.2014.09.024 [Meta-analysis, 5 RCTs, n=593]
- Araya-Quintanilla F, Gutierrez-Espinoza H, Munoz-Yanez MJ, Sanchez-Montoya U, Lopez-Jeldes J. Effectiveness of Ginger on Pain and Function in Knee Osteoarthritis: A PRISMA Systematic Review and Meta-Analysis. Pain Physician. 2020;23(2):E151-E161. PMID: 32214292 [Meta-analysis, 7 studies, knee osteoarthritis]
- Atkins T, Manger S, Albarqouni L. Ginger for the treatment and prevention of migraine headaches: a systematic review and meta-analysis of randomised controlled trials. BMJ Evid Based Med. 2026. Epub 14.08.2026. PMID: 42601183 · DOI: 10.1136/bmjebm-2025-114382 [Meta-analysis, 8 RCTs, n=594]
- Martins LB, Rodrigues AMDS, Monteze NM, Tibaes JRB, Amaral MHA, Gomez RS, Teixeira AL, Ferreira AVM. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine. Cephalalgia. 2020;40(1):88-95. PMID: 31398997 · DOI: 10.1177/0333102419869319 [RCT, n=107]
- Wu KL, Rayner CK, Chuah SK, Changchien CS, Lu SN, Chiu YC, Chiu KW, Lee CM. Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol. 2008;20(5):436-40. PMID: 18403946 · DOI: 10.1097/MEG.0b013e3282f4b224 [RCT, crossover, n=24]
- Crichton M, Marshall S, Marx W, Isenring E, Vázquez-Campos X, Dawson SL, Lohning A. Effect of Ginger Root Powder on Gastrointestinal Bacteria Composition, Gastrointestinal Symptoms, Mental Health, Fatigue, and Quality of Life: A Double-Blind Placebo-Controlled Trial. J Nutr. 2023;153(11):3193-3206. PMID: 37690779 · DOI: 10.1016/j.tjnut.2023.09.002 [RCT, n=51]
- Chen X, Cheng S, Zhang D. Meta-analysis of the effects of ginger supplementation on glycemic control, blood pressure and lipid profile in patients with type 2 diabetes. Syst Rev. 2026;15(1):231. PMID: 42337792 · DOI: 10.1186/s13643-026-03251-5 [Meta-analysis, 13 papers]
- Schumacher JC, Mueller V, Sousa C, Peres KK, da Mata IR, Menezes RCR, Dal Bosco SM. The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis. Clin Nutr ESPEN. 2024;63:615-622. PMID: 39053695 · DOI: 10.1016/j.clnesp.2024.07.011 [Meta-analysis, 5 RCTs]
- Salih AK, Alwan AH, Khadim M, Al-Qaim ZH, Mardanov B, El-Sehrwy AA, Ahmed YI, Amerizadeh A. Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta-analysis. Phytother Res. 2023;37(6):2472-2483. PMID: 36786398 · DOI: 10.1002/ptr.7769 [Meta-analysis, RCTs 2010 to 2022]
- Rafieipour N, Gharbi N, Rahimi H, Kohansal A, Sadeghi-Dehsahraei H, Fadaei M, et al. Ginger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of 27 randomized controlled trials. Nutr Rev. 2024;82(12):1651-1665. PMID: 38261398 · DOI: 10.1093/nutrit/nuad149 [Meta-analysis, 27 RCTs, n=1309]
- Karimi M, Asbaghi O, Rafiei H, Kazemi K, Yazdizadeh S, Radman G, Hosseini R, Hosseini MH, Sabet M, Goudarzi MA. Ginger Supplementation and Blood Pressure in Adults: A GRADE-Based Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. J Hum Nutr Diet. 2026;39(4):e70329. PMID: 42566667 · DOI: 10.1111/jhn.70329 [Meta-analysis, 12 RCTs]
- Ghoreishi PS, Shams M, Nimrouzi M, Zarshenas MM, Lankarani KB, Fallahzadeh Abarghooei E, Talebzadeh M, Hashempur MH. The Effects of Ginger (Zingiber Officinale Roscoe) on Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blinded Placebo-Controlled Clinical Trial. J Diet Suppl. 2024;21(3):294-312. PMID: 37817641 · DOI: 10.1080/19390211.2023.2263788 [RCT, n=76]
- Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol. 2013;145(1):146-51. PMID: 23123794 · DOI: 10.1016/j.jep.2012.10.043 [In vitro, cell lines]
- Banihani SA. Ginger and Testosterone. Biomolecules. 2018;8(4):119. PMID: 30360442 · DOI: 10.3390/biom8040119 [Review, mostly in vivo data]
- Marx W, McKavanagh D, McCarthy AL, Bird R, Ried K, Chan A, Isenring L. The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review. PLoS One. 2015;10(10):e0141119. PMID: 26488162 · DOI: 10.1371/journal.pone.0141119 [Systematic Review, 10 studies]
- Jiang X, Williams KM, Liauw WS, Ammit AJ, Roufogalis BD, Duke CC, Day RO, McLachlan AJ. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2005;59(4):425-32. PMID: 15801937 · DOI: 10.1111/j.1365-2125.2005.02322.x [RCT, crossover, n=12]
- Shalansky S, Lynd L, Richardson K, Ingaszewski A, Kerr C. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. Pharmacotherapy. 2007;27(9):1237-47. PMID: 17723077 · DOI: 10.1592/phco.27.9.1237 [Cohort, n=171]
- Hatfield J, Saad S, Housewright C. Dietary supplements and bleeding. Proc (Bayl Univ Med Cent). 2022;35(6):802-807. PMID: 36304597 · DOI: 10.1080/08998280.2022.2121575 [Review]
- Saads Carvalho T, Lussi A. Chapter 9: Acidic Beverages and Foods Associated with Dental Erosion and Erosive Tooth Wear. Monogr Oral Sci. 2020;28:91-98. PMID: 31940633 · DOI: 10.1159/000455376 [Review]
- Kuderer S, Vagedes K, Szöke H, Kohl M, Joos S, Gündling PW, Vagedes J. Do ginger footbaths improve symptoms of insomnia more than footbaths with warm water only? - A randomized controlled study. Complement Ther Med. 2022;67:102834. PMID: 35439548 · DOI: 10.1016/j.ctim.2022.102834 [RCT, n=28]
- Vagedes J, Kuderer S, Vagedes K, Szőke H, Kohl M, Joos S, Beissner F, Wolf U. Do Chest Compresses with Mustard or Ginger Affect Warmth Regulation in Healthy Adults? A Randomized Controlled Trial. Evid Based Complement Alternat Med. 2022;2022:5034572. PMID: 35899230 · DOI: 10.1155/2022/5034572 [RCT, crossover, n=18]
- Commission E is reproduced here only via two consistent secondary sources, because the original text was not accessible. A daily dose from this monograph is therefore not given.
- British guideline 2024: the statement on ginger was checked against the full text of the final version. It appears in the text on severe nausea and hyperemesis and carries no recommendation grade of its own, so none is cited. The wording of the ACOG recommendation comes from a secondary source.
- Pregnancy: the umbrella review rates the effect against nausea with high GRADE certainty, while the HMPC rates the quality of the underlying studies as low. These are different yardsticks, and both assessments stand side by side in the text.
- Colds: the statement that no clinical study was found refers to a targeted PubMed search on 16.09.2026. It is not proof that ginger does nothing for colds.
- Mechanisms: anti-inflammatory action via immune cells, inhibition of 5-HT3 receptors, RSV inhibition and the rise in testosterone come from cell culture and animal experiments. They are marked as such and not transferred to humans.
- Still open: the relevance of ginger for coagulation during long-term therapy, the risk in gallstone disease, the long-term safety of concentrated shots in pregnancy, and interactions with diabetes and blood pressure medication.
- Numbers: study results are taken from the abstracts without conversion; in this English version, decimal points replace the decimal commas of the German original. Meta-analyses with high heterogeneity are named as such.
- What is deliberately not here: no dosing recommendation, no brands, no product recommendation and no advice to stop, reduce or replace a prescribed medication. No paragraph implies that obstetric, oncological, gastroenterological or neurological treatment should be postponed. Observations of effects from my practice are deliberately not included.