Nutrition Guide · Organ Meats and Bone Broth

Organ meats, bone broth and the forgotten parts

Liver is one of the most nutrient dense foods we know. That same density is also its limit, and with bone broth the marketing and the measured values sit far apart.

SJ
Shukri Jarmoukli · Physician, Integrative Medicine · ViveCura Berlin
Nutrient density Safety limits Nose to Tail 31 studies with DOI
Why I am writing this

We did not stop eating the whole animal because organ meats had become unhealthy. Supermarkets, prosperity and a trained sense of disgust shrank the animal down to a muscle cut. Two things disappeared with it that muscle meat barely delivers: the nutrient density of the organs and the glycine of connective tissue. And that very density is the reason liver is not an everyday food.

There is an image many of us carry from childhood. Liver with onions on the table. The smell drifting through the whole flat. And at least one person pulling a face.

Maybe you were that child. Maybe you cook for yourself today and still would never buy a beef liver. That is not a quirk, it is a shift across two generations.

In my consultations beef liver still comes up regularly, usually from two directions. Some people have read that liver is the most nutrient dense food there is. Others have heard that liver is dangerous. Each group has not read the other half. The same goes for bone broth. I bring both worlds together here, with numbers instead of adjectives.

What to expect here

  • Why the whole animal shrank to the muscle
  • Beef liver against steak in USDA numbers
  • The vitamin A ceiling, early and clearly
  • What the EFSA says on frequency and pregnancy
  • Copper, purines and the open question of origin
  • Why a carrot is not the same as liver for everyone
  • Glycine and methionine: the forgotten balance
  • Bone broth: measured values and the open lead question
  • Collagen: myth, peptides and the sober meta-analysis
RCT / Meta randomised in humans Observation cohort, measurement, agency Animal animal model Cell culture test tube

How we shrank from the whole animal to one muscle cut

Ask your grandmother what she cooked on Sundays. Often the answer is tongue, kidney, heart or liver dumplings. Ask her great grandchildren the same question. The answer is chicken breast.

What lies between those two answers is not a medical insight. It is refrigeration, prosperity and the self service aisle. Organ meats spoil quickly, smell strong and need craft. Muscle meat can be portioned and standardised. It simply fits an industry better.

How far the retreat has gone shows up in a footnote of official statistics. Since 2022 the German meat supply balance assigns by-products to the carcass, and a separate balance for offal no longer exists. The category has lost its place in the bookkeeping.

Review What food science says about it

A research group in Lublin reviewed ten years of literature on edible offal in 2024. Their core sentence: the nutrient concentration of offal often clearly exceeds that of skeletal muscle. At the same time they describe how much edible organ tissue is produced per carcass and never reaches a plate for cultural reasons.

For you that means: what we left out is not the worst part of the animal. It is the most inconvenient one.

Latoch et al., Nutrients 2024. DOI: 10.3390/nu16111609 · PMID: 38892542 [Review]

This text continues another one. The article on meat, cancer, origin and processing is about which meat was processed how. Here we look at the question before that: which parts still appear at all. The Paleo and AIP perspective picks this up too, usually without the safety side.

Reframe

Nose to tail is not a nutrition trend, it is the normal state we walked away from. Eating the whole animal is not the new thing. Eating only the muscle is.

And now you know why the question is not whether organ meats are fashionable, but what disappeared along with them.

What is in liver, and why the number is almost uncomfortable

I pulled the values straight from the nutrient database of the US Department of Agriculture so you can check them yourself. Raw beef liver against lean beef steak, per 100 g. The calorie content is almost identical, 135 against 131. Everything else is not.

Per 100 gBeef liver, rawLean steak, rawFactor
Vitamin A (RAE)4,968 µg0 µgnot calculable
Vitamin B1259.3 µg1.09 µg54 times
Folate290 µg13 µg22 times
Copper9.755 mg0.075 mg130 times
Riboflavin2.755 mg0.111 mg25 times
Choline333.3 mg92.3 mg3.6 times
Iron4.9 mg1.61 mg3 times
Protein20.36 g22.09 g0.9 times

USDA FoodData Central, SR Legacy, fdcId 169451 and 174055, queried on 20 August 2026. European values may differ, especially for vitamin A.

Picture the liver as a warehouse and the muscle as a workshop. The liver stores, processes, distributes. That is why the fat soluble vitamins, the copper and the vitamin B12 sit there. A warehouse always holds more than a workshop.

Database analysis The global nutrient density ranking

Ted Beal and Flaminia Ortenzi built a worldwide food database in 2022 and calculated the density of six commonly scarce micronutrients for five population groups. Organs come out on top, followed by small fish, dark green leafy vegetables and shellfish.

For you that means: the sentence “liver is extremely nutrient dense” is well supported. It says nothing about how often you should eat it.

Beal & Ortenzi, Frontiers in Nutrition 2022. DOI: 10.3389/fnut.2022.806566 · PMID: 35321287 [Review]

Two points of context. The iron in liver is largely heme iron, and everything about that sits in the article on iron absorption. And these vitamins are not numbers for their own sake, they are cofactors in energy metabolism, see the piece on the cofactors between calorie and energy.

Reframe

Liver is not a food with a lot of nutrients in it. Liver is a concentrate that happens to look like a piece of meat.

And now you know why almost every kitchen gave it a special status. It was never a food you ate to get full.

The limit that comes with that density: vitamin A

Here comes the part that enthusiastic liver pages usually leave out. Not out of bad intent, but because it complicates a nice story.

The same vitamin A that makes liver so valuable is a storage compound. Fat soluble, not easily excreted, with an upper limit. The European food safety authority reviewed it in 2024 and kept it at 3,000 µg retinol equivalents per day, for adults, explicitly including women of childbearing age.

4,968 µg vitamin A as RAE in 100 g of raw beef liver
3,000 µg tolerable upper intake level per day per EFSA
166 % of that ceiling delivered by a single 100 g serving

So one serving does not sit just below the limit, it sits two thirds above it. And now the sentence that appears almost nowhere in the popular guides, even though you can read it in an agency document.

European populations are unlikely to exceed the upper level for preformed vitamin A if the consumption of liver, offal and products made from them is limited to once a month or less.

EFSA NDA Panel, 2024, paraphrased

Once a month or less. Not once a week. The weekly rule circulates everywhere, yet I find no agency source for it. No scandal, just a number that took on a life of its own.

Pregnancy: please read this closely

The EFSA explicitly advises women who are pregnant or would like to become pregnant against liver products, including liver sausage and liver pâté. The background is the evidence on harm to the developing child at high intakes of preformed vitamin A.

The German Federal Institute for Risk Assessment calls the safety margin between the upper level and actual intake very small, and recommends vitamin A supplements in pregnancy only after medical consultation. For postmenopausal women it proposes 1.5 mg per day because of the bone data.

Ate liver by accident? No reason to panic, but a reason to raise it with the practice caring for you. A single portion and a sustained intake are different things.

Cohort, n=22,748 Where the caution in pregnancy comes from

Kenneth Rothman and his team surveyed 22,748 pregnant women in the 1980s about diet and supplements in the first trimester. Above 15,000 international units of preformed vitamin A per day, the prevalence ratio for malformations arising from the cranial neural crest was 3.5, compared with 5,000 units or less.

For you that means: this is an observational study, so an association and not a proven cause. But 10,000 units correspond to roughly 3,000 µg retinol, which is about one small serving of liver.

Rothman et al., N Engl J Med 1995. DOI: 10.1056/NEJM199511233332101 · PMID: 7477116 [Cohort, n=22,748]

A second safety thread concerns men and older people. In a Swedish cohort of 2,322 men followed over thirty years, the highest fifth of serum retinol showed a rate ratio of 1.64 for fractures and 2.47 for hip fractures, while beta-carotene showed none. A meta-analysis of 13 studies confirms the direction and makes the finding smaller: hip fractures yes, relative risk 1.29, overall fracture risk no.

Reframe

Liver is not dangerous. Liver is concentrated. That is the same sentence from two directions, and both are true at once.

The difference between a food and too much lies not in the amount per bite, but in the frequency over months. And now you know why the question is not whether liver is healthy, but how often.

Copper, purines and the question of where the animal lived

Vitamin A is the best known limit, but not the only one. As far as I can see, nobody does the arithmetic on the second one.

Copper appears on the plus side in almost every text about liver. It sits in enzymes of energy metabolism, in iron metabolism and in connective tissue. All correct. Except that 100 g of beef liver contain 9.755 mg of it.

Agency document What the copper re-evaluation says

The EFSA Scientific Committee re-evaluated the guidance values for copper in 2023, using storage in the liver as an early marker of possible adverse effects. The result: at 5 mg per day no copper retention is expected.

For you that means: one serving of liver sits at double that value. No argument against a rare serving, but very much an argument against a daily one.

EFSA Scientific Committee, EFSA Journal 2023. DOI: 10.2903/j.efsa.2023.7728 · PMID: 36694841 [Agency document]

The third limit is called purines and concerns only some people. A Japanese research group analysed 270 foods by HPLC: chicken liver 312.2 mg total purines per 100 g, pork liver 284.8 mg, beef liver 219.8 mg. The frequently cited daily recommendation for gout prevention sits under 400 mg. A 150 g serving of chicken liver fills that account on its own.

One nuance belongs here, otherwise this turns into a blanket verdict. In a prospective cohort of 47,150 men over twelve years, meat and seafood raised gout risk, while purine rich vegetables and total protein intake did not. So purine is not simply purine, and protein as such is not the issue. How much of it makes sense sits in the article on how much protein you need.

Open question: origin

The liver is a filtering and storage organ. What an animal takes in over years accumulates there more readily than in the muscle. Alongside vitamin A, the German BfR explicitly names dioxins and dioxin like PCBs, which can reach animals through their feed.

It follows logically that husbandry and feed matter more for offal than for muscle. To be honest about it: I found no solid endpoint studies showing that liver from pasture raised animals carries less. The plausibility is high, the data are thin.

And now you know why with organ meats I talk more about origin and frequency than about the amount on the plate.

Why a carrot is not the same as liver for some people

At this point almost everyone says: then I will just eat carrots, there is vitamin A in those too.

Sort of. A carrot contains beta-carotene, a precursor. Your body has to convert it into retinol first, and for that it needs the enzyme BCMO1. Picture a factory hall where raw material becomes product. Some people have a fast hall, some a slow one. That is partly genetic.

Mechanism plus human trial Two common gene variants, one large difference

A group around Wei Chun Leung screened the BCMO1 gene, characterised the enzyme variants in the lab and gave volunteers a defined beta-carotene dose. Two common variants turned up with allele frequencies of 42 and 24 percent. The double variant showed 57 percent less catalytic activity, and in the volunteers conversion was reduced by up to 69 percent.

For you that means: for many people a carrot really is not the same as liver. That still does not justify a high liver intake, because the upper limit stays where it is.

Leung et al., FASEB J 2009. DOI: 10.1096/fj.08-121962 · PMID: 19103647 [Mechanism Review]

This is one of the lenses that interests me most in integrative work: the genetic one. It explains why two people eating the same way can have different blood values. More on that in the article about genes, ancestry and metabolism.

The takeaway

Beta-carotene has a brake, retinol does not. That is why an oversupply of vitamin A through carrots is hardly possible, while through liver it is. And now you know why I never answer a vitamin A question with a food, but with a question about the course over time.

Glycine and methionine: the balance few people talk about

Now comes the part that fascinates me most professionally and where I also have to phrase things most carefully.

When you eat a steak, you eat muscle. When your grandmother cooked a soup with shank, rind and cartilage, she ate connective tissue along with it. Biochemically those are not the same food. Their amino acid profiles differ, and not by a little.

2 to 1 glycine to methionine in beef steak, 1.345 g against 0.575 g
31 to 1 glycine to methionine in gelatine, 19.05 g against 0.606 g
around 10 g calculated daily glycine gap at 70 kg body weight

Glycine is the smallest amino acid there is, and in collagen it occupies every third position of the helix. It is also needed for heme, creatine, bile acids and glutathione. Picture glycine as a person standing in four queues at the same time. That works as long as there is enough of it.

Balance calculation The calculation that started this topic

A group around Enrique Meléndez-Hevia put all published fluxes for glycine production and glycine consumption side by side in 2009. Available, by their reckoning, are around 3 g per day from endogenous synthesis and 1.5 to 3.0 g from food. For all metabolic purposes that leaves a calculated shortfall of about 10 g per day.

For you that means: this is a balance calculation from literature values, not a measured deficiency. A deficit on paper is not yet a clinical picture.

Meléndez-Hevia et al., J Biosci 2009. DOI: 10.1007/s12038-009-0100-9 · PMID: 20093739 [Mechanism Review]

Why is that more than playing with numbers? Because methionine sits abundantly in muscle meat and glycine mostly in connective tissue. A review classes glycine as conditionally essential and names glutathione as the main consumer, see the article on glutathione and detoxification.

In vivo, mouse What happened in the animal model

In the American Interventions Testing Program a diet with 8 percent glycine was tested at three sites. The lifespan of genetically mixed mice rose by 4 to 6 percent, statistically significant, without increased accompanying pathology.

For you that means: these are mice. The finding supports the idea mechanistically, it proves nothing in humans.

Miller et al., Aging Cell 2019. DOI: 10.1111/acel.12953 · PMID: 30916479 [In vivo, mouse]

A second image is almost too neat. Cheetahs in captivity are fed muscle meat, while in the wild they eat whole prey. A South African group supplemented ten cheetahs with glycine for four weeks in 2025, after which certain metabolic pathways shifted measurably. The authors themselves call the health relevance unknown. Ten big cats are an illustration, not a proof.

In humans there is so far one well conducted but very small study. 24 older adults received glycine plus N-acetylcysteine or placebo for 16 weeks, after which glutathione levels, oxidative stress and physical function improved. One centre, small sample, combination product. That proves nothing for glycine alone and nothing for bone broth.

Reframe

The interesting question is not whether you eat too much meat. It is whether you eat only the muscle. A diet of fillet, breast and mince shifts the methionine to glycine ratio considerably. That is the only point where this text touches the carnivore diet.

Traditional kitchens solved the question in passing by cooking skin, cartilage, tendons and bones along with everything else. Not out of wisdom, but out of thrift. And now you know why I qualify every second sentence here: the mechanism is elegant, the human data are thin.

Bone broth: what is in it, what gets oversold, and the open lead question

Maybe you have seen a jar of bone broth for seven euros and wondered whether that is a food or a supplement. The answer decides which expectation is reasonable.

What is actually in it: during long cooking, collagen from bones, cartilage and skin breaks down into gelatine. That is why a good broth gels in the fridge. Gelatine consists largely of glycine and proline. That is the measurable core of the story.

Lab analysis The analysis that decides this chapter

Rebekah Alcock, Gregory Shaw and Louise Burke analysed commercial and homemade bone broths for the key amino acids. With standardised preparation, all values sat significantly below those of a potentially therapeutic dose of 20 g of a reference collagen supplement. Commercial broths came in lower still.

For you that means: the idea is not refuted, the reliability is. Your broth and a measured powder are two different things.

Alcock, Shaw & Burke, Int J Sport Nutr Exerc Metab 2019. DOI: 10.1123/ijsnem.2018-0139 · PMID: 29893587 [Review]

And the minerals? A Taiwanese group looked at this under controlled conditions. Lowering the pH from 8.38 to 5.32, meaning the classic splash of vinegar, raised calcium and magnesium extraction by a factor of 17.4 and 15.3 respectively, and cooking times beyond eight hours did the same. Even so, both stayed below five percent of the daily intake per serving. The vinegar trick works measurably, it just does not change the order of magnitude.

Two studies, two answers: the lead question

The same Taiwanese work also measured heavy metals and concluded that the risk from lead and cadmium was minimal, because the contents amounted to a few micrograms per serving.

A British group had emphasised the opposite in 2013 in a small blinded examination of three organic chicken broths: all contained several times the lead concentration of the water used. Broth from skin and cartilage came in at 9.5 µg per litre, chicken bone broth at 7.01, the tap water at 0.89.

I deliberately leave this contradiction standing. Three samples in a hypothesis journal are a different class of evidence from controlled laboratory experiments, and a relative comparison with water is something other than an absolute amount per cup. In practice that means: the origin of the bones matters, and large amounts every day are a different scenario from an occasional cup.

Two findings that often get told too big belong here for fairness. In a mouse model of chemically induced colitis, pre-treatment with beef bone broth reduced histological damage: a possible mechanism, not an argument for people with bowel disease. And the famous chicken soup study from 2000 slowed the migration of neutrophils in a chamber in the lab, not in a person with a cold.

The takeaway

Bone broth is good food and a poor supplement. It can be warm, filling and easy on the stomach. What it cannot do is deliver what studies with measured doses examined. And now you know why I never talk anyone out of their broth and still push back when it is sold as a therapy.

Collagen: the myth, the peptides and the sober meta-analysis

The idea is seductive and printed on many packages. You eat collagen, it travels into your skin, your wrinkles get fewer. Digestion does not work that way.

Collagen is a protein and gets taken apart like any other. A brick house you transport does not arrive as a house, it arrives as bricks. What gets built from them is decided by the building site, not by the transport. Except that the findings are now finer than that picture.

Human trial, kinetics What shows up in the blood after eating

A Japanese group around Kenji Iwai gave healthy volunteers gelatine hydrolysates on an empty stomach and took blood over several hours. Peptide bound hydroxyproline was barely detectable beforehand and rose afterwards to 20 to 60 nmol per millilitre of plasma. The main component was the dipeptide Pro-Hyp.

For you that means: collagen does not arrive as collagen, but also not only as loose amino acids, rather as characteristic fragments. Whether more collagen is built in the tissue from them remains open.

Iwai et al., J Agric Food Chem 2005. DOI: 10.1021/jf050206p · PMID: 16076145 [Review]
RCT, n=8, cross-over Gelatine plus vitamin C before exercise

Gregory Shaw and Keith Baar gave eight healthy men 5 g or 15 g of vitamin C enriched gelatine or placebo in a double blind design, one hour before six minutes of rope skipping. At 15 g the collagen formation marker P1NP was twice as high as under placebo.

For you that means: the mechanism is plausible. So are the limits: eight men, a surrogate marker, no measured injury rates.

Shaw et al., Am J Clin Nutr 2017. DOI: 10.3945/ajcn.116.138594 · PMID: 27852613 [RCT, n=8]

For joint complaints there are several positive randomised studies. 139 active people with knee problems took 5 g of collagen peptides for twelve weeks, with a significant improvement in activity related pain. Of 147 randomised athletes, 97 remained evaluable after 24 weeks on 10 g of collagen hydrolysate, and six pain parameters improved in them. And in 131 postmenopausal women the T-score rose slightly over twelve months, while it fell in the control group.

If I stopped here, you would have read an advertisement.

Meta-analysis, k=69 The sober assessment

Xiaoqian Liu and David Hunter summarised all randomised studies on 20 supplements in osteoarthritis in 2018. Seven of them, collagen hydrolysate among them, showed large short term pain reductions. In the medium term two remained meaningful, in the long term none did. The authors rate the certainty of evidence as very low.

For you that means: the positive individual studies are real, but they describe short windows and small differences.

Liu et al., Br J Sports Med 2018. DOI: 10.1136/bjsports-2016-097333 · PMID: 29018060 [Meta-analysis, k=69]

One piece of transparency I consider important. Several of the positive collagen studies come from the same constellation, the University of Freiburg together with a collagen research institute in Kiel. That does not make them wrong, but it belongs in the assessment.

For skin the picture looks more robust. Three independent meta-analyses with 19, 26 and 14 studies found improvements in skin moisture and elasticity compared with placebo. The largest one names several risks of bias itself. Almost all participants were women, and the endpoints are device measurements.

Reframe

The myth does not hold, and the subject stays interesting anyway. Collagen you eat does not land as collagen in your skin, but it leaves measurable traces in the blood, and in several studies small changes followed.

So collagen peptides are neither nothing nor a miracle. And now you know why I first ask people who want to buy collagen what they expect from it.

What makes sense if you never want to become an offal eater

Maybe you have read this far and are thinking: nice, but I am still not buying liver. Completely fine. Disgust is a real signal, and eating against yourself is rarely a good idea.

The way out is a change of perspective. Do not think in foods, think in nutrients. Liver is not a magical unit, it is a bundle of six or seven things, and you can get most of them elsewhere.

Nutrient by nutrient instead of food by food

  • Choline. The quietest nutrient on the list. In US surveys only around 8 percent of adults reached the adequate intake, while egg eaters were at nearly double the amount.
  • Glycine. Through connective tissue cuts, shank, rind, chicken skin, gelatine and collagen peptides. In the studies gelatine was combined with vitamin C.
  • Vitamin B12 and folate. Reachable through other animal foods, and with a plant based diet B12 belongs in the planning: vegan nutrition and eating vegetarian long term.
  • Iron. Its own building site with its own mechanics, covered in detail in the article on iron absorption.
  • Vitamin A. The one point where less often is the better direction. Here you need no substitute, you need restraint.
  • Copper. Plentiful in nuts, cocoa, whole grains and seafood. A deficiency is rare in central Europe.

If instead your curiosity is piqued, small portions and long gaps are the whole trick. This is not about a superfood, it is about the quality of what sits on the plate. That is also what the articles on unprocessed food, the calorie myth and omega-3 from plants, animals and algae revolve around.

In my consultations I see a recurring pattern. People arrive with a yes or no question about liver and leave with a different one: what does my own course look like, which values do I know, which stage of life am I in right now. No blog article can do that sorting for you. If you would like to discuss it in person, you will find the option to book an appointment below this article.

To take with you

Nose to tail is a good idea with a clear limit. The organs give you density, the connective tissue gives you glycine, and both together were once normal. What is new is the knowledge about the upper limits. That is not a step backwards, that is precision.

And now you know why the forgotten parts of the animal are neither a superfood nor a risk, but a food with very clear instructions for use.

Common questions about organ meats, liver and bone broth

How often can I eat liver?

In its 2024 opinion the EFSA puts it like this: anyone who limits liver, offal and products made from them to once a month or less is unlikely to exceed the tolerable upper intake level for preformed vitamin A. That is considerably more cautious than the once-a-week rule circulating online, for which hardly any agency source can be found. For children the upper levels are lower still, because they are derived from body weight.

How much vitamin A is in beef liver?

The USDA database lists 4,968 µg retinol activity equivalents per 100 g of raw beef liver. The tolerable upper intake level for adults is 3,000 µg per day. A single serving therefore sits roughly two thirds above it. The content also varies widely with species, age and feeding, so European values may differ. That very spread is one reason to choose the frequency carefully.

Can I eat liver or liver sausage during pregnancy?

The EFSA explicitly advises women who are pregnant or planning to become pregnant against liver products. The German BfR recommends taking vitamin A supplements during pregnancy only after medical consultation, and describes the safety margin for preformed vitamin A as very small. The background is the risk of malformations at high intakes, especially in the first weeks of pregnancy. If you are unsure, this question belongs with the practice caring for you and not in an online forum.

Is bone broth really healthy or just a trend?

It is a warm, well tolerated, protein containing food, and in culinary terms it needs no defence. As a mineral source it is weak: in one laboratory analysis calcium and magnesium per serving stayed below five percent of the daily requirement. As a collagen source it is unreliable, because concentrations vary a great deal from recipe to recipe. If you see it as good food, you are right. If you see it as a supplement, you expect too much.

Is collagen powder better than homemade bone broth?

For a defined amount, yes. An analysis of real broths found the decisive amino acids well below the reference dose of roughly 20 g used in studies, with wide variation depending on the recipe. Commercial broths came in below the homemade ones. If you are looking for an effect like the one seen in studies, you need a measurable dose. If you are looking for a good soup, you do not.

Does the collagen you eat really reach your skin and joints?

Not as collagen. It is digested like any other protein. What can be measured in the blood are characteristic small peptides, above all Pro-Hyp, peaking one to two hours after intake. Whether more collagen is built in the tissue as a result is the real research question, and the answer is a cautious maybe. The picture of collagen landing as collagen in your skin does not hold up in that form.

How long does bone broth need to simmer, and why the vinegar?

In one controlled experiment, cooking times beyond eight hours brought significantly more calcium and magnesium into the broth. Lowering the pH from 8.38 to 5.32, meaning the classic splash of vinegar, increased extraction by a factor of 17 and 15 respectively. The absolute amount still stayed small. So the vinegar trick works measurably, it just does not change the order of magnitude.

Is lead in bone broth a problem?

Here two investigations contradict each other. One found several times the lead concentration of the water used in chicken bone broth, up to 9.5 µg per litre against 0.89 µg per litre. The other measured absolute amounts per serving and rated the risk as minimal. The honest answer: the question is not settled. Someone drinking large amounts daily is in a different situation from someone having the occasional cup.

Why is glycine an issue when you eat muscle meat?

Because muscle and connective tissue are biochemically different. 100 g of beef steak contain roughly 1.3 g glycine and 0.6 g methionine, gelatine powder around 19 g glycine and 0.6 g methionine. If you only eat fillet, you shift that ratio considerably. Glycine is needed for collagen and for glutathione, among other things. That is mechanistically interesting, though the human studies on it are still thin.

Are organ meats off limits with gout?

They are among the most purine rich foods there are. Measurements found 312.2 mg total purines per 100 g in chicken liver, 284.8 mg in pork liver and 219.8 mg in beef liver, against a frequently cited daily recommendation of under 400 mg. The nuance is interesting: in a large cohort study, purine rich vegetables and total protein intake did not raise gout risk, while meat and seafood did. With known gout this question belongs in medical care.

Do organ meats carry contaminants?

The liver is a metabolic and storage organ, so it accumulates. Alongside vitamin A the German BfR explicitly names environmental contaminants such as dioxins and dioxin like PCBs, which reach the animals through feed and can build up. The same principle applies to copper: 9.755 mg per 100 g of beef liver sits against a value of 5 mg per day at which no retention is expected. Whether liver from pasture raised animals carries less is a question that solid endpoint studies currently cannot answer.

What do I do if I simply cannot get organ meats down?

Think nutrient by nutrient instead of food by food. Choline is well covered by eggs; in US data only around 8 percent of adults reached the adequate intake, while egg eaters were at nearly double the amount. Glycine comes from connective tissue cuts, gelatine and collagen peptides, sensibly together with vitamin C. For iron there is a separate detailed article. And with vitamin A, less often really is the better direction.

Where this topic leads next

Organ meats and bone broth touch on more than the question of what sits on the plate. They lead to the liver as an organ, to connective tissue, to the fat soluble vitamins and to glycine in entirely different contexts. Here are four ways out of this article.

SJ

Shukri Jarmoukli

Physician, Integrative Medicine · ViveCura Berlin

I work in my private practice at the intersection of conventional medicine, functional medicine and Clinical Psychoneuroimmunology. With nutrition questions I am less interested in which food is currently traded as a superfood, and more in what the numbers actually show, where the limits sit, and what that means for one individual person with their own history.

This article does not replace medical advice. It is meant to help you ask better questions before you buy, cook or leave something out.

ViveCura, Privatpraxis Shukri Jarmoukli, Skalitzer Straße 137, 10999 Berlin

Scientific sources

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Transparency on the evidence The nutrient figures in this article come from the US American USDA database, not from a European food composition table. With vitamin A in liver in particular, the values vary strongly with species, age and feeding. That spread argues for more caution rather than less. The safety statements on vitamin A and copper rest on agency documents from EFSA and BfR and are well supported. The glycine gap of around 10 g per day is a balance calculation from literature values and not a deficiency measured in patients; the supporting findings come from a mouse study, an examination of ten cheetahs and a very small combination product RCT with 24 people. With collagen, positive randomised studies stand against a meta-analysis with very low certainty of evidence, and several of the positive works come from the same research constellation in Freiburg and Kiel. The skin meta-analyses point in the same direction, but name risks of bias themselves and rest almost entirely on studies in women. The lead question in bone broth is open: a controlled laboratory study gives the all clear, a small examination of three samples urges caution, and I deliberately leave that contradiction standing. Whether offal from pasture raised animals really carries less is a question the currently available endpoint studies cannot answer. I have tried to make visible at every point where solid data end and where interpretation begins.

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